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Fig. 6 | BMC Nephrology

Fig. 6

From: Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

Fig. 6

Spironolactone (SPL) reduces (a) cytosolic and (b) mitochondrial reactive oxidative species (ROS) production in human aortic endothelial cells (HAECs) stimulated by advanced glycation end products (AGEs) at a concentration of 200 μg/ml. Pre-treatment of AGEs-stimulated HAECs with anti-AGEs neutralizing antibody (Aby) at a concentration of 50 μg/ml or N-acetylcysteine (NAC) at a concentration of 20 mM was used as a positive control. * any groups compared with the vehicle, p < 0.05; $ any groups compared with the AGEs (200 μg/mL)

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BMC Nephrology

ISSN: 1471-2369

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