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Fig. 8 | BMC Nephrology

Fig. 8

From: Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

Fig. 8

Application of confocal microscopy to illustrate differences in fluorescence intensity of nicotinamide adenine dinucleotide phosphate oxidase (NOX-2) between different groups. Human aortic endothelial cells (HAECs) treated with the vehicle were used as a negative control group. Compared with the AGEs-stimulated group, pre-treatment with spironolactone (10 μM) in AGEs-stimulated HAECs resulted in a lower fluorescence intensity of NOX-2. Pre-treatment with tenovin-6 (1 μM; the AGEs + spironolactone + tenovin-6 group) resulted in a higher NOX-2 fluorescence intensity than did the AGEs + Spironolactone group

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BMC Nephrology

ISSN: 1471-2369

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