Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass

Gelsomino, Sandro; Bonacchi, Massimo; Lucà, Fabiana; Barili, Fabio; Del Pace, Stefano; Parise, Orlando; Johnson, Daniel M.; Gulizia, Michele Massimo

doi:10.1186/s12882-019-1564-y

Table 2 Predictive performance and discrimination power

From: Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass

		eGFR	AUC	95% CI	De Long	Bootstrap	Venkatraman	Somers	Brier
All		CKD-EPI	0.77	0.73–0.81	< 0.01^*	< 0.01^*	< 0.01^*	0.54	0.01
		MDRD	0.55	0.50–0.61	0.65^†	0.61^†	0.76^†	0.11	0.02
		CG	0.52	0.47–0.57	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.04	0.02
eGFR	> = 60 ml/min./1.73m²	CKD-EPI	0.78	0.73–0.82	< 0.01^*	< 0.01^*	< 0.01^*	0.55	0.01
		MDRD	0.57	0.50–0.63	< 0.01^†	< 0.01^†	< 0.01^†	0.13	0.02
		CG	0.73	0.69–0.75	0.57^‡	0.54^‡	0.60^‡	0.44	0.01
	45–59 ml/min./1.73m²	CKD-EPI	0.67	0.57–0.77	< 0.01^*	< 0.01^*	< 0.01^*	0.34	0.01
		MDRD	0.59	0.49–0.69	< 0.01^†	< 0.01^†	< 0.01^†	0.18	0.02
		CG	0.65	0.60–0.69	0.67^‡	0.66^‡	0.69^‡	0.30	0.01
	30–44 ml/min./1.73m²	CKD-EPI	0.63	0.55–0.71	0.04^*	0.04^*	0.04^*	0.25	0.03
		MDRD	0.53	0.40–0.67	0.45^†	0.43^†	0.55^†	0.07	0.05
		CG	0.57	0.43–0.71	0.04^‡	0.04^‡	0.04^‡	0.15	0.04
	<=29 ml/min./1.73m²	CKD-EPI	0.53	0.35–0.71	0.35^*	0.32^*	0.54^*	0.06	0.13
		MDRD	0.65	0.48–0.82	0.10^†	0.09^†	0.16^†	0.30	0.14
		CG	0.49	0.27–0.71	0.23^‡	0.20^‡	0.28^‡	0.02	0.13
Age	AGE > =60 y	CKD-EPI	0.68	0.63–0.74	< 0.01^*	< 0.01^*	< 0.01^*	0.37	0.02
		MDRD	0.57	0.51–0.63	0.58^†	0.52^†	0.63^†	0.14	0.03
		CG	0.54	0.48–0.60	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.09	0.03
	AGE 40–59 y	CKD-EPI	0.81	0.70–0.92	< 0.01^*	< 0.01^*	< 0.01^*	0.62	0.02
		MDRD	0.59	0.48–0.70	< 0.01^†	< 0.01^†	< 0.01^†	0.17	0.03
		CG	0.86	0.80–0.91	0.45^‡	0.41^‡	0.52^‡	0.72	0.01
	AGE 18–39 y	CKD-EPI	0.82	0.72–0.96	< 0.01^*	< 0.01^*	< 0.01^*	0.64	0.06
		MDRD	0.57	0.46–0.72	0.03^†	0.02^†	0.04^†	0.14	0.09
		CG	0.47	0.08–0.85	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.06	0.12
Gender	Male	CKD-EPI	0.76	0.71–0.82	< 0.01^*	< 0.01^*	< 0.01^*	0.53	0.01
		MDRD	0.55	0.49–0.61	0.04^†	0.04^†	0.04^†	0.10	0.02
		CG	0.51	0.45–0.57	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.03	0.02
	Female	CKD-EPI	0.72	0.66–0.78	< 0.01^*	< 0.01^*	< 0.01^*	0.44	0.02
		MDRD	0.55	0.43–0.66	0.03^†	0.03^†	0.04^†	0.09	0.04
		CG	0.50	0.43–0.57	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.01	0.06
Weight	> = 100 Kg	CKD-EPI	0.81	0.66–0.97	0.01^*	0.01^*	0.02^*	0.63	0.05
		MDRD	0.50	0.31–0.70	0.04^†	0.04^†	0.04^†	0.01	0.07
		CG	0.48	0.26–0.69	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.04	0.08
	80–99 Kg	CKD-EPI	0.77	0.69–0.84	< 0.01^*	< 0.01^*	< 0.01^*	0.53	0.01
		MDRD	0.52	0.41–0.62	0.04^†	0.04^†	0.04^†	0.04	0.02
		CG	0.50	0.40–0.62	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.03	0.03
	60–79 Kg	CKD-EPI	0.79	0.74–0.84	< 0.01^*	< 0.01^*	< 0.01^*	0.59	0.01
		MDRD	0.56	0.49–0.63	0.02^†	0.02^†	0.03^†	0.12	0.02
		CG	0.50	0.43–0.57	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.01	0.03
	<=59 Kg	CKD-EPI	0.69	0.56–0.83	0.01^*	0.03^*	0.02^*	0.39	0.03
		MDRD	0.55	0.41–0.69	0.48^†	0.45^†	0.56^†	0.11	0.03
		CG	0.53	0.38–0.68	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.07	0.04
BMI	> = 30 Kg/m²	CKD-EPI	0.81	0.71–0.92	< 0.01^*	< 0.01^*	< 0.01^*	0.63	0.01
		MDRD	0.53	0.37–0.69	0.03^†	0.03^†	0.04^†	0.06	0.02
		CG	0.46	0.28–0.64	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.06	0.03
	25–29 Kg/m²	CKD-EPI	0.76	0.70–0.82	< 0.01^*	< 0.01^*	< 0.01^*	0.52	0.01
		MDRD	0.55	0.47–0.63	0.01^†	< 0.01^†	0.02^†	0.10	0.02
		CG	0.45	0.37–0.53	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.01	0.04
	18.5–24 Kg/m²	CKD-EPI	0.77	0.70–0.83	< 0.01^*	< 0.01^*	< 0.01^*	0.53	0.01
		MDRD	0.57	0.49–0.66	0.00^†	< 0.01^†	0.01^†	0.15	0.02
		CG	0.47	0.39–0.56	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.04	0.04
	<=18.5 Kg/m²	CKD-EPI	0.77	0.62–0.92	0.04^*	0.04^*	0.04^*	0.54	0.14
		MDRD	0.52	0.27–0.66	0.65^†	0.62^†	0.70^†	0.03	0.13
		CG	0.53	0.13–0.94	< 0.01^‡	< 0.01^‡	< 0.01^‡	0.07	0.12

Best performance for: Brier score = 0, AUC = 1, Somers’ Dxy = 1. Abbreviations: eGFR: estimated Glomerular Filtration Rate; CI: Confidence Interval; CKD-EPI: Chronic Kidney Disease-Epidemiology Collaboration Formula; MDRD: Modification of Diet in Renal Disease Formula; CG: Cockroft-Gault Formula; BMI: Body Mass Index.* CKD-EPI vs MDRD; † MDRD vs CG; ‡ CG vs CKD-EPI

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