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Table 1 Clinical characteristics and outcomes in patients with and without moderate to severe AKI progression

From: Early detection of acute kidney injury in the perioperative period of liver transplant with neutrophil gelatinase-associated lipocalin

PATIENT CHARACTERISTICS AND OUTCOMES

Total

No AKI/mild AKI

Severe AKI

p

N

100 (100%)

41 (41%)

59 (59%)

< 0.0001

Baseline Characteristics

 Age

58 (12)

57 (12)

53 (12)

0.01

 Gender (Male)

64 (64%)

27 (42%)

37 (58%)

0.75

 BMI

26 (4)

26 (4)

26.5 (5)

0.65

 Non caucasian

14 (14%)

05 (36%)

09 (64%)

0.11

 MELD functional

15 (11–19)

14 (10–17)

16 (12–22)

0.01

 MELD LT

29 (29–29)

29 (29–29)

29 (29–32)

0.96

Liver Disease

 hepatitis C

46 (46%)

17(37%)

29(63%)

0.44

 Alcoholic cirrhosis

13 (13%)

06(46%)

07(54%)

0.68

 Cryptogenic cirrhosis

12 (12%)

05(42%)

07(58%)

0.96

 acute hepatitis

06 (06%)

03(50%)

03(50%)

0.64

 hepatitis B

04 (04%)

02(50%)

02(50%)

0.70

 Other

19 (19%)

08(42%)

11(57%)

0.91

Comorbidities

 Hypertension

33(33%)

12(36%)

21(64%)

0.43

 Diabetes mellitus

28 (28%)

14 (50%)

14 (50%)

0.26

Kidney function

 baseline sCr

0.77 (0.63–0.99)

0.77 (0.62–0.98)

0.77 (0.65–1.00)

0.87

 reference sCr

0.78 (0.62–1.02)

0.77 (0.64–1.02)

0.80 (0.61–1.00)

0.96

 Estimated GFR (CKD-EPI) by Scr ref.

78.65 (52–99)

93.50 (64–105)

69.40 (45–98)

0.013

 Estimated GFR (CKD-EPI) by Scr base

99.65 (74–110)

99.25 (75–108)

108.52 (69–117)

0.67

 Urine output first day after LT

475 (45)

608 (79)

383 (49)

0.01

 Fluid balance first day after LT

+ 1535 (+ 500–2315)

+ 1010 (+ 367–1782)

+ 1655 (+ 890–2447)

0.008

Severity score indices

 SAPS

64 (60–72)

64 (11)

69 (15)

0.68

 SOFA

13 (11–15)

12 (10–13)

14 (12–16)

0.001

process of care

 Anesthesia time

09:56 (01:59)

09:08 (01:33)

10:32 (02:04)

< 0.0001

 HEPATECTOMY TIME (HH:MM)

03:11 (00:54)

02:54 (00:46)

03:27 (00:57)

0.003

 warm ischemia time (HH:MM)

00:42 (1:11)

00:41 (1:21)

00:43 (1:52)

> 0.0001

 cold ischemia time (HH:MM)

06:04 (01:55)

05:49 (02:06)

06:14 (01:46)

0.73

 Red blood cELLS (unit)

2.39 (2.8)

1.45 (2.57)

3 (2.9)

0.002

outcomes

 Time with vasoactive drugs (days)

2 (1.78)

1(1.18)

2 (2)

0.01

 Days of Mechanical ventilation

2 (1.82)

1 (0.57)

3 (2)

< 0.0001

 Lenght of ICU stay (days)

9.81 (13)

5.59 (6.3)

12.75 (2)

0.003

 Lenght of hospital stay (days)

29 (28)

19.17 (14.6)

36 (4.2)

< 0.0001

 Need for Retransplant

11 (11%)

01 (09%)

10 (91%)

0.02

 Need for RRT

36 (36%)

04 (10.5%)

34 (89.5%)

< 0.0001

 60 day Mortality

21 (21%)

03 (14.3%)

18 (85.7%)

0.004

  1. Data are expressed as n (%), mean (±), median and percentile (25–75) according to their distribution. Time of anesthesia expressed as hours: minutes. BMI (body mass index), MELD (model for end-stage liver disease), LT (liver transplant), ICU (intensive unit care), SAPS (Simplified Acute Physiology Score), SOFA (Sequential Organ Failure Assessment), RRT (renal replacement therapy), GFR (glomerular filtration rate), CKD- Epidemiology Collaboration