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Table 1 Clinical characteristics and outcomes in patients with and without moderate to severe AKI progression

From: Early detection of acute kidney injury in the perioperative period of liver transplant with neutrophil gelatinase-associated lipocalin

PATIENT CHARACTERISTICS AND OUTCOMES Total No AKI/mild AKI Severe AKI p
N 100 (100%) 41 (41%) 59 (59%) < 0.0001
Baseline Characteristics
 Age 58 (12) 57 (12) 53 (12) 0.01
 Gender (Male) 64 (64%) 27 (42%) 37 (58%) 0.75
 BMI 26 (4) 26 (4) 26.5 (5) 0.65
 Non caucasian 14 (14%) 05 (36%) 09 (64%) 0.11
 MELD functional 15 (11–19) 14 (10–17) 16 (12–22) 0.01
 MELD LT 29 (29–29) 29 (29–29) 29 (29–32) 0.96
Liver Disease
 hepatitis C 46 (46%) 17(37%) 29(63%) 0.44
 Alcoholic cirrhosis 13 (13%) 06(46%) 07(54%) 0.68
 Cryptogenic cirrhosis 12 (12%) 05(42%) 07(58%) 0.96
 acute hepatitis 06 (06%) 03(50%) 03(50%) 0.64
 hepatitis B 04 (04%) 02(50%) 02(50%) 0.70
 Other 19 (19%) 08(42%) 11(57%) 0.91
Comorbidities
 Hypertension 33(33%) 12(36%) 21(64%) 0.43
 Diabetes mellitus 28 (28%) 14 (50%) 14 (50%) 0.26
Kidney function
 baseline sCr 0.77 (0.63–0.99) 0.77 (0.62–0.98) 0.77 (0.65–1.00) 0.87
 reference sCr 0.78 (0.62–1.02) 0.77 (0.64–1.02) 0.80 (0.61–1.00) 0.96
 Estimated GFR (CKD-EPI) by Scr ref. 78.65 (52–99) 93.50 (64–105) 69.40 (45–98) 0.013
 Estimated GFR (CKD-EPI) by Scr base 99.65 (74–110) 99.25 (75–108) 108.52 (69–117) 0.67
 Urine output first day after LT 475 (45) 608 (79) 383 (49) 0.01
 Fluid balance first day after LT + 1535 (+ 500–2315) + 1010 (+ 367–1782) + 1655 (+ 890–2447) 0.008
Severity score indices
 SAPS 64 (60–72) 64 (11) 69 (15) 0.68
 SOFA 13 (11–15) 12 (10–13) 14 (12–16) 0.001
process of care
 Anesthesia time 09:56 (01:59) 09:08 (01:33) 10:32 (02:04) < 0.0001
 HEPATECTOMY TIME (HH:MM) 03:11 (00:54) 02:54 (00:46) 03:27 (00:57) 0.003
 warm ischemia time (HH:MM) 00:42 (1:11) 00:41 (1:21) 00:43 (1:52) > 0.0001
 cold ischemia time (HH:MM) 06:04 (01:55) 05:49 (02:06) 06:14 (01:46) 0.73
 Red blood cELLS (unit) 2.39 (2.8) 1.45 (2.57) 3 (2.9) 0.002
outcomes
 Time with vasoactive drugs (days) 2 (1.78) 1(1.18) 2 (2) 0.01
 Days of Mechanical ventilation 2 (1.82) 1 (0.57) 3 (2) < 0.0001
 Lenght of ICU stay (days) 9.81 (13) 5.59 (6.3) 12.75 (2) 0.003
 Lenght of hospital stay (days) 29 (28) 19.17 (14.6) 36 (4.2) < 0.0001
 Need for Retransplant 11 (11%) 01 (09%) 10 (91%) 0.02
 Need for RRT 36 (36%) 04 (10.5%) 34 (89.5%) < 0.0001
 60 day Mortality 21 (21%) 03 (14.3%) 18 (85.7%) 0.004
  1. Data are expressed as n (%), mean (±), median and percentile (25–75) according to their distribution. Time of anesthesia expressed as hours: minutes. BMI (body mass index), MELD (model for end-stage liver disease), LT (liver transplant), ICU (intensive unit care), SAPS (Simplified Acute Physiology Score), SOFA (Sequential Organ Failure Assessment), RRT (renal replacement therapy), GFR (glomerular filtration rate), CKD- Epidemiology Collaboration