Non-adherence to Haemodialysis, Interdialytic weight gain and cardiovascular mortality: a cohort study

BMC Nephrology

Table 3 Cox proportional hazard model for all-cause mortality

Risk factors	Unadjusted		Multivariate
Risk factors	HR (CI 95%)	p	HR (CI 95%)	p
Age (years)	1.04 (1.03–1.06)	< 0.001	1.04 (1.02–1.06)	< 0.001
Time in haemodialysis (years)	1.04 (0.99–1.09)	0.11	1.04 (0.97–1.11)	0.21
Cardiovascular or cerebrovascular disease (yes)	2.28 (1.50–3.47)	< 0.001	1.80 (1.16–2.79)	0.009
Diabetes Mellitus (yes)	1.83 (1.13–2.97)	0.014	0.66 (0.39–1.11)	0.12
Smoking (presently or prior)	1.46 (0.96–2.23)	0.075	1.04 (0.66–1.62)	0.85
Anuria (yes)	1.39 (0.91–2.12)	0.126	1.57 (0.96–2.55)	0.07
Vascular access (catheter)	1.71 (0.86–3.42)	0.12	0.62 (0.29–1.28)	0.20
Status for kidney transplant (not apt)	1.73 (1.05–2.86)	0.03	1.70 (0.59–4.89)	0.32
BMI between 18.5–24.9 Kg/m²	1 (reference)	0.015	1 (reference)
BMI between 25 and 29.9 Kg/m²	1.54 (0.94–2.53)	0.085	1.45 (0.88–2.38)	0.14
BMI ≥ 30 Kg/m²	1.14 (0.51–2.55)	0.73	0.94 (0.41–2.11)	0.87
BMI < 18.5 Kg/m²	2.83 (1.54–5.22)	0.001	2.24 (1.19–4.20)	0.012
Serum albumin (g/dL)	0.65 (0.41–1.03)	0.07	0.81 (0.50–1.31)	0.39
% period of HD performed/prescribed	1.05 (0.99–1.13)	0.09	1.00 (0.95–1.06)	0.77
IDWG < 3% of DW	1 (reference)	0.17	1 (reference)
IDWG 3–3.99% of DW	0.81 (0.46–1.44)	0.29	0.89 (0.49–1.61)	0.69
IDWG ≥4% of DW	1.31 (0.79–2.17)	0.18	2.02 (1.17–3.49)	0.012

HR Hazard ratio, CI confidence interval, BMI body mass index, IDWG interdialytic weight gain, DW dry weigh
Other variable assessed in the univariate analysis: sex, race, systemic arterial hypertension, background of parathyroidectomy, spKt/V, Parathormone ≥600 pg/mL, Serum phosphorus > 5.5 mg/dL, Ultrafiltration (ml/h/Kg)

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