Fig. 2

Grouped Boxplot Diagram. To investigate whether differences in platelet function were due to presence of chronic kidney disease (CKD) or major depressive disorder (MDD), comparisons were made between 49 patients with MDD and CKD (MDD+/CKD+), 15 non-depressed controls with normal kidney function (MDD−/CKD-) and 28 non-depressed controls with CKD (MDD−/CKD+) using non-parametric ANOVA on ranked outcomes. Panel a Represents comparison of whole blood platelet aggregation induced by agonists including collagen, arachidonic acid (AA), adenosine diphosphate (ADP). Overall P = 0.03 for difference between 3 groups for WBPA induced by 10 μM ADP and P = 0.02 for 20 μM of ADP; Panel b Represents comparison of platelet ATP secretion induced by agonists including collagen, arachidonic acid (AA), and thrombin; and, Panel c Represents comparison of plasma levels of P-selectin (CD62P) and E-selectin (CD62E). Asterisks represent significant p-values in pairwise comparisons