Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial

Jain, Nishank; Wan, Fei; Kothari, Monica; Adelodun, Anuoluwapo; Ware, Jerry; Sarode, Ravi; Hedayati, S. Susan

doi:10.1186/s12882-019-1576-7

Table 2 Correlations of Depression Severity at Baseline and Serum Sertraline and N-desmethylsertraline Levels at Exit with Platelet Function in Patients with Major Depressive Disorder and Chronic Kidney Disease

From: Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial

	Spearman correlation coefficient	P-value
Depression Severity at baseline by QIDS-SR₁₆ Score^a	N = 175
WBPA to 0.5 mM arachidonic acid, Ω	− 0.05	0.55
WBPA to 0.25 mM arachidonic acid, Ω	− 0.06	0.46
WBPA to 20 μM ADP, Ω	− 0.16	0.06
WBPA to 10 μM ADP, Ω	− 0.11	0.16
WBPA to 2 μg/mL collagen, Ω	−0.10	0.18
ATP secretion to 0.5 mM arachidonic acid, nmoles	−0.04	0.63
ATP secretion to 0.25 mM arachidonic acid, nmoles	−0.02	0.79
ATP secretion to 2 μg/mL collagen, nmoles	−0.14	0.06
ATP secretion to 1 unit/mL thrombin, nmoles	−0.06	0.45
^bPlasma P-selectin levels, pg/L	0.06	0.61
^bPlasma E-selectin levels, pg/L	0.00953	0.93
^cSerum Sertraline levels, pg/L	0.21	0.01
^cSerum N-desmethylsertraline levels, pg/L	0.18	0.03
Serum Sertraline Levels in pg/L
WBPA to 0.5 mM arachidonic acid, Ω	−0.0089	0.93
WBPA to 0.25 mM arachidonic acid, Ω	− 0.0650	0.51
WBPA to 20 μM ADP, Ω	−0.1092	0.35
WBPA to 10 μM ADP, Ω	0.0341	0.7
WBPA to 2 μg/mL collagen, Ω	−0.0154	0.88
ATP secretion to 0.5 mM arachidonic acid, nmoles	−0.08725	0.38
ATP secretion to 0.25 mM arachidonic acid, nmoles	− 0.1472	0.14
ATP secretion to 2 μg/mL collagen, nmoles	− 0.1513	0.12
ATP secretion to 1 unit/mL thrombin, nmoles	−0.2200	0.03
^bPlasma P-selectin levels, pg/L	−0.0946	0.50
^bPlasma E-selectin levels, pg/L	−0.2076	0.14
Serum N-desmethylsertraline levels in pg/L
WBPA to 0.5 mM arachidonic acid, Ω	− 0.0045	0.96
WBPA to 0.25 mM arachidonic acid, Ω	− 0.0553	0.59
WBPA to 20 μM ADP, Ω	−0.1063	0.37
WBPA to 10 μM ADP, Ω	0.0510	0.60
WBPA to 2 μg/mL collagen, Ω	−0.0164	0.87
ATP secretion to 0.5 mM arachidonic acid, nmoles	−0.0789	0.43
ATP secretion to 0.25 mM arachidonic acid, nmoles	−0.1237	0.22
ATP secretion to 2 μg/mL collagen, nmoles	−0.1287	0.20
ATP secretion to 1 unit/mL thrombin, nmoles	−0.2012	0.04
^bPlasma P-selectin levels, pg/L	−0.0554	0.40
^bPlasma E-selectin levels, pg/L	−0.2166	0.12

Abbreviations: ADP Adenosine diphosphate, ATP Adenosine triphosphate, QIDS-SR₁₆ 6-item Quick Inventory for Depression Symptomatology Self-Report, WBPA- whole blood platelet aggregation, Ω, ohms
^aBaseline (visit 1) values were used for the QIDS- SR₁₆
^bPlasma samples available on 90 participants at randomization (Visit 1) and 50 participants at study exit (Visit 6) for P-selectin and E-selectin
^cSerum samples available on 140 participants at study exit (Visit 6) for Sertraline and N-desmethylsertraline levels

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ISSN: 1471-2369

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