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Table 2 Changes in clinical parameters from baseline in hypoalbuminemic patients

From: Changes in serum albumin and other nutritional markers when using sucroferric oxyhydroxide as phosphate binder among hemodialysis patients: a historical cohort study

Parameter

Baseline

SO therapy

Mean change from baseline

−Q2

−Q1

Q1

Q2

Q3

Q4

PB pills/d

7.9 [0.2]a

8.9 [0.2]

3.9 [0.2]a

4.0 [0.2]a

4.0 [0.2]a

4.1 [0.2]a

−4.9 [0.5]a

sP (mg/dL)

5.93 [0.16]a

6.79 [0.15]

6.48 [0.15]c

6.41 [0.15]c

6.33 [0.15]b

6.25 [0.15]a

−0.40 [0.11]c

sAlb (g/dL)

3.41 [0.03]a

3.50 [0.03]

3.69 [0.03]a

3.74 [0.03]a

3.70 [0.03]a

3.69 [0.03]a

+ 0.18 [0.03]a

nPCR (g/kg/d)

0.81 [0.03]a

0.90 [0.03]

0.93 [0.02]ns

0.93 [0.02]ns

0.91 [0.02]ns

0.91 [0.02]ns

+ 0.03 [0.02]ns

Phosphorus-attuned albumin (×  103)

0.62 [0.01]a

0.55 [0.01]

0.61 [0.01]a

0.62 [0.01]a

0.64 [0.01]a

0.65 [0.01]a

+ 0.08 [0.01]a

Phosphorus-attuned nPCR (× 103 dL/kg/d)

0.15 [0.02]ns

0.14 [0.02]

0.15 [0.02]c

0.15 [0.02]c

0.16 [0.02]b

0.16 [0.02]a

+ 0.02 [0.01]a

Pre-dialysis weight (kg)

89.2 [2.8]ns

89.1 [2.8]

90.2 [2.8]c

91.4 [2.8]a

91.8 [2.8]a

92.5 [2.8]a

+ 2.2 [2.2]a

Post-dialysis weight (kg)

86.5 [2.8]ns

86.3 [2.8]

87.3 [2.8]c

88.5 [2.8]a

88.9 [2.8]a

89.5 [2.8]a

+ 2.1 [1.7] a

Equilibrated Kt/V

1.41 [0.03]ns

1.45 [0.03]

1.49 [0.03]ns

1.45 [0.03]ns

1.47 [0.03]ns

1.43 [0.03]ns

+ 0.014 [0.02]ns

Serum creatinine (mg/dL)

8.7 [0.4]b

9.4 [0.4]

9.7 [0.4]ns

10.0 [0.4]b

10.0 [0.4]b

9.8 [0.4]c

+ 0.6 [0.6]b

iPTH (pg/mL)

528 [43]ns

568 [42]

569 [41]ns

552 [41]ns

579 [41]ns

536 [41]ns

−17 [45]ns

Corrected calcium (mg/dL)

9.3 [0.1]ns

9.3 [0.1]

9.3 [0.1]ns

9.2 [0.1]c

9.2 [0.1]c

9.2 [0.1]c

−0.08 [0.1]ns

  1. Summary statistics are expressed as LS means [standard errors]
  2. Abbreviations: iPTH intact parathyroid hormone, LS least-square, nPCR normalized protein catabolic rate, ns non-significant, PB phosphate binder, sAlb serum albumin, SO sucroferric oxyhydroxide, sP serum phosphorus
  3. All comparisons were carried out with −Q1 as the reference. aP < 0.0001, bP < 0.001, cP < 0.05, nsnon-significant