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Table 3 Changes in clinical parameters from baseline in non-hypoalbuminemic patients

From: Changes in serum albumin and other nutritional markers when using sucroferric oxyhydroxide as phosphate binder among hemodialysis patients: a historical cohort study

Parameter

Baseline

SO therapy

Mean change from baseline

−Q2

−Q1

Q1

Q2

Q3

Q4

PB pills/d

8.4 [0.2]c

8.9 [0.2]

3.7 [0.2]a

3.8 [0.2]a

3.8 [0.2]a

3.8 [0.2]a

−5.0 [0.5]a

sP (mg/dL)

6.65 [0.16]ns

6.83 [0.16]

6.39 [0.16]a

6.41 [0.16]a

6.37 [0.16]a

6.43 [0.16]b

−0.51 [0.12]a

sAlb (g/dL)

4.05 [0.02]ns

4.03 [0.02]

4.01 [0.02]ns

4.02 [0.02]ns

4.01 [0.02]ns

3.97 [0.02]c

−0.02 [0.03]ns

nPCR (g/kg/d)

0.98 [0.02]ns

0.97 [0.02]

0.96 [0.02]ns

0.96 [0.02]ns

0.95 [0.02]ns

0.94 [0.02]ns

−0.02 [0.02]ns

Phosphorus-attuned albumin (× 103)

0.65 [0.02]c

0.62 [0.02]

0.67 [0.02]a

0.67 [0.02]a

0.69 [0.02]a

0.68 [0.02]a

+ 0.06 [0.01]a

Phosphorus-attuned nPCR (× 103 dL/kg/d)

0.16 [0.01]ns

0.15 [0.01]

0.16 [0.01]c

0.16 [0.01]c

0.16 [0.01]b

0.16 [0.01]c

+ 0.01 [0.01]c

Pre-dialysis weight (kg)

91.1 [3.2]ns

90.9 [3.2]

91.4 [3.2]c

91.2 [3.2]ns

91.2 [3.2]ns

91.1 [3.2]ns

+ 0.5 [0.4]ns

Post-dialysis weight (kg)

88.2 [3.1]ns

88.1 [3.1]

88.4 [3.1]ns

88.3 [3.1]ns

88.2 [3.1]ns

88.2 [3.1]ns

+ 0.4 [0.4]ns

Equilibrated Kt/V

1.48 [0.02]ns

1.51 [0.02]

1.52 [0.02]ns

1.51 [0.02]ns

1.49 [0.02]ns

1.48 [0.02]ns

−0.008 [0.02]ns

Serum creatinine (mg/dL)

9.7 [0.3]ns

9.8 [0.3]

9.9 [0.3]ns

10.0 [0.3]ns

9.8 [0.3]ns

9.8 [0.3]ns

+ 0.08 [0.1]ns

iPTH (pg/mL)

609 [64]ns

633 [64]

651 [63]ns

656 [63]ns

643 [63]ns

763 [63]b

+ 49 [44]ns

Corrected calcium (mg/dL)

9.1 [0.07]ns

9.2 [0.07]

9.2 [0.07]ns

9.1 [0.07]ns

9.1 [0.07]ns

9.1 [0.07]ns

−0.04 [0.05]ns

  1. Summary statistics are expressed as LS means [standard errors]
  2. Abbreviations: iPTH intact parathyroid hormone, LS least-square, nPCR normalized protein catabolic rate, ns nonsignificant, PB phosphate binder, sAlb serum albumin, SO sucroferric oxyhydroxide, sP serum phosphorus
  3. All comparisons were carried out with −Q1 as the reference. aP < 0.0001, bP < 0.001, cP < 0.05, nsnon-significant