Fig. 4

Renal histopathology in MRL/lpr mice. a Histopathological features of the studied mouse renal tissues determined by H&E. b Immunohistological findings for renal tissues from MRL/lpr mice treated by CRIg/FH at 10 mg/kg twice weekly and normal saline (NS). The NS treated mice showed significant glomerular atrophy, basement membrane thickening and rupture, mesangial area widening, mesangial matrix increases, mesangial cell proliferation and deposition of components of immunopathogenesis; MRL/lpr mice revealed less renal damage and immunological deposition. NS = normal saline, Pred = prednisone, MAC = membrane attack complex. The CRIg/FH treatment at indicated dose was administrated twice a week