Impact of prior stroke on major clinical outcome in chronic kidney disease: the Salford kidney cohort study

BMC Nephrology

Table 2 A comparison of outcomes between patients with a history of stroke at recruitment compared with those without

Outcome	Stroke at recruitment		P Value (stroke at recruitment v no stroke at recruitment)
Outcome	No N = 2833	Yes N = 227	P Value (stroke at recruitment v no stroke at recruitment)
Non-Fatal Stroke	81 (2.9%)	20 (8.8%)	0.000
Non-Fatal Myocardial infarction	154 (5.4%)	24 (10.6%)	0.001
Non-fatal cardiovascular events	319 (11.3%)	60 (26.4%)	0.000
ESRD	884 (30.6%)	90 (49.6%)	0.004
First method of RRT
Dialysis	542 (61.3%)	37 (41.1%)	0.000
Transplant	83 (9.4%)	8 (8.9%)	0.835
eGFR < 10	259 (29.3%)	45 (50%)	0.000
All-cause mortality	1275 (45%)	157 (69.2%)	0.000
Death from cardiovascular disease^a	174 (43.5%)	31 (57.5%)	0.048
Death from stroke^a	19 (4.75%)	6 (1.2%)	0.052
Age at death (years)^b	77 (70–83)	77 (71–83)	0.959
Months in study	38 (16–71)	28 (10–62)	0.001
eGFR progression slope (mL/min/1.73m²/year)^c	−1.35 (−4.08, 0.70)	−1.54 (−3.77, 0.26)	0.527

Continuous variables expressed as median (interquartile range) and categorical variables presented as number (%)
Non-fatal cardiovascular events variable represents a composite of stroke, transient ischaemic attack, non-fatal myocardial infarction, coronary revascularisation including coronary artery bypass grafting and cardiac arrest
Abbreviations: non-fatal cardiovascular events Non-fatal cardiovascular event, ESRD End Stage Renal Disease, eGFR estimated glomerular filtration fate (CKD-EPI)
^abased on cause of death data available for 457patients (403 no stroke at recruitment patients and 54 patients with stroke at recruitment), cardiovascular disease includes a composite of stroke, myocardial infarction, heart failure, peripheral vascular disease, aortic aneurysm
^bbased upon 1432 deaths
^cbased upon 2885 patients who had more than 2 creatinine measurements during study

ISSN: 1471-2369