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Table 3 Interactions between tested SNPs significant in unadjusted analyzes in HD patients not receiving lipid-lowering medication

From: Calcium-sensing receptor gene (CASR) polymorphisms and CASR transcript level concerning dyslipidemia in hemodialysis patients: a cross-sectional study

CHR1

GENE1

SNP1

CHR2

GENE2

SNP2

The odds ratio for interaction

Chi-square

P-value

FDR-adjusted P-value

Patients with dyslipidemia by K/DOQI vs. patients without this phenotype

 9

ENHO

rs2281997

9

RXRA

RXRA

1.7690

7.007

0.0081

0.3645

Patients with LDL-cholesterol ≥100 mg/dL vs. patients without this phenotype

 3

CASR

rs1801725

9

RXRA

rs10881578

0.6030

4.048

0.0442

0.9916

 9

ENHO

rs2281997

9

RXRA

rs749759

1.8920

8.794

0.0030

0.1350

Patients with non-HDL-cholesterol ≥130 mg/dL and TG ≥ 200 mg/dL vs patients without this phenotype

 9

ENHO

rs2281997

11

LXRA

rs2279238

2.4220

5.962

0.0146

0.3285

 9

RXRA

rs10881578

9

RXRA

rs749759

0.4213

9.829

0.0017

0.0765

Patients with atherogenic index ≥3.8 vs. patients without this phenotype

 3

CASR

rs7652589

9

ENHO

rs72735260

0.5744

4.680

0.0305

0.8595

 9

ENHO

rs2281997

11

LXRA

rs2279238

1.7750

4.298

0.0382

0.8595

Patients with dyslipidemia by K/DOQI vs. patients without dyslipidemia by all used criteria

 9

ENHO

rs2281997

9

RXRA

rs749759

1.767

5.528

0.0187

0.8415

Patients with LDL-cholesterol ≥100 mg/dL vs. patients without dyslipidemia by all used criteria

 9

ENHO

rs2281997

9

RXRA

rs749759

1.945

6.839

0.0089

0.4005

Patients with non-HDL-cholesterol ≥130 mg/dL and TG ≥ 200 mg/dL vs. patients without dyslipidemia by all used criteria

 9

ENHO

rs2281997

11

LXRA

rs2279238

2.604

5.017

0.0251

0.5648

 9

RXRA

rs10881578

9

RXRA

rs749759

0.485

5.743

0.0166

0.5648

Patients with atherogenic index ≥3.8 vs. patients without dyslipidemia by all used criteria

 3

CASR

rs7652589

9

ENHO

rs72735260

0.564

3.904

0.0482

0.8162

  1. P-values adjusted for FDR equal to or below 0.25 are considered significant and are indicated using a bold font.
  2. Abbreviations: CHR1 Chromosome of first SNP, SNP1 Identifier for first SNP, GENE1 Gene of the first SNP, CHR2 Chromosome of second SNP, SNP2 Identifier for second SNP, GENE2 Gene of the second SNP, P-value 1df asymptotic P-value, FDR-adjusted P-value P-value adjusted for false discovery rate