Calcium-sensing receptor gene (CASR) polymorphisms and CASR transcript level concerning dyslipidemia in hemodialysis patients: a cross-sectional study

Table 4 CASR rs7652589 polymorphic variants and serum lipids in HD patients not receiving lipid-lowering medication (n = 666)

Parameter	GG	AG	AA	Model of inheritance	P-value¹	P-value²
Parameter	n = 250	n = 320	n = 96	Model of inheritance	P-value¹	P-value²
Total cholesterol, mg/dL	171.5 (72–282)	174.5 (65–363)	164.5 (92–296)	AG + AA vs. GG	0.883	0.024
				AA vs. GG + AG	0.311	0.420
				AA vs. GG	0.442	0.097
HDL-cholesterol, mg/dL	42 (6–94)	39 (10–118)	39 (17.3–82)	AG + AA vs GG	0.011	0.864
				AA vs. GG + AG	0.376	0.455
				AA vs. GG	0.070	0.412
Triglycerides, mg/dL	131.3 (40–585)	140.5 (35–1105)	140 (35–406)	AG + AA vs. GG	0.067	0.027
				AA vs. GG + AG	0.680	0.284
				AA vs. GG	0.671	0.061
LDL-cholesterol, mg/dL	94.6 (27.8–208.4)	98 (20–350)	92.5 (27–369)	AG + AA vs. GG	0.705	0.126
				AA vs. GG + AG	0.480	0.545
				AA vs. GG	0.612	0.239
Non-HDL-cholesterol, mg/dL	125 (52–234)	132 (8–282)	120 (58–262)	AG + AA vs. GG	0.430	0.037
				AA vs. GG + AG	0.432	0.332
				AA vs. GG	0.737	0.079
TG/HDL-cholesterol ratio	3.1 (0.6–30.8)	3.6 (0.4–34.5)	3.4 (0.5–15)	AG + AA vs. GG	0.015	0.037
				AA vs. GG + AG	0.971	0.177
				AA vs. GG	0.325	0.041

Conversion factors to SI units are as follows: for cholesterols – 1 mg/dL = 0.0259 mmol/L, for triglycerides – 1 mg/dL = 0.0113 mmol/L.
Significant differences are indicated using a bold font.
1 – Mann Whitney test; 2 – P-value for rs7652589 SNP in a linear regression model including gender, age, BMI, diabetic nephropathy, coronary artery disease, and alkaline phosphatase activity

ISSN: 1471-2369