Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study

Table 2 Crude and Adjusted odds ratios determined by multivariate analysis exploring risk factors associated with AKI

	Crude odds ratio (95%CI)	Adjusted odds ratio (95%CI)	p-value
Age, per 10 year increase	1.10 (1.002; 1.018)	1.11 (0.999; 1.260)	0.079
Male gender	1.22 (0.92; 1.608)	1.44 (1.008; 2.058)	0.045
Diabetes	1.88 (1.228; 2.945)	1.69 (0.982; 2.947)	0.059
Baseline CKD	0.64 (0.382; 1.066)	0.32 (0.163; 0.634)	0.001
Receiving HAART	1.95 (1.245; 3.137)	1.64 (0.940; 2.920)	0.086
Admission SOFA score	1.48 (1.391; 1.585)	1.33 (1.215; 1.456)	< 0.001
SAPS 3 score	1.07 (1.062; 1.088)	1.03 (1.013; 1.047)	< 0.001
ICU length of stay, days	1.12 (1.081; 1.155)	1.04 (1.007; 1.072)	0.026
Required mechanical ventilation	3.05 (2.299; 4.072)	0.56 (0.359; 0.860)	0.003
Required vasopressors	11.15 (6.954; 18.878)	2.52 (1.392; 4.700)	0.003
Developed ARDS	12.39 (3.734; 76.752)	3.20 (0.840; 21.071)	0.137
Developed sepsis or septic shock	5.50 (3.839; 8.038)	1.81 (1.119; 2.929)	0.016
HIV Infection^a	1.42 (0.952; 2.15)	0.60 (0.272; 1.305)	0.198

Abbreviations: HAART Highly Active Antiretroviral Therapy, SOFA Sequential Organ Failure Assessment, SAPS 3 Simplified Acute Physiology Score 3, ARDS Acute Respiratory Distress Syndrome. ^a Analysis restricted to only those with a known HIV serostatus (n = 472)

ISSN: 1471-2369