Effect of curcumin on adenine-induced water intake change in rats (A) Daily recordings of the mean water intake changes of the experimental groups of rats and (B) comparison of the mean water intake of rats prior to (open columns) and after treatment (closed columns) either with the adenine-supplemented diet alone or with curcumin. Each bar represents the mean ± SEM of 5–6 rats. Significant difference from normal control at identical times: ### p < 0.001. Significant difference from CKD control rats at identical times: *** p < 0.001. Significant difference from the respective pre-treated value: a p < 0.001. No significant difference from the respective pre-treated value: b (p > 0.05). CUR = Curcumin.