Effect of curcumin on adenine-induced food intake change in rats (A) Daily recordings of the mean food intake changes of the experimental groups of rats and (B) comparison of the mean food intake of rats prior to (open columns) and after treatment (closed columns) either with the adenine-supplemented diet alone or with curcumin. Each bar represents the mean ± SEM of 5–6 rats. Significant difference from normal control at identical times: ### p < 0.001. Significant difference from normal control before the treatment: a p < 0.001. Significant difference from CKD control rats at identical times: *** p < 0.001. No significant difference from the respective pre-treated value: b (p > 0.05). CUR = Curcumin.