parameter | 1 week after RT (1) | 3 months after RT (2) | 6 months after RT (3) | 1 year after RT (4) | 3 years after RT (5) | p | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1vs2 | 1vs3 | 1vs4 | 1vs5 | 2vs3 | 3vs5 | 4vs5 | ||||||
LV dimensions | ||||||||||||
LVEDd [mm] | 52.3 ± 5.0 | 49.8 ± 4.4 | 50.0 ± 4.7 | 49.9 ± 4.6 | 49.5 ± 4.7 | 0.012 | 0.016 | 0.001 | < 0.001 | 0.953 | 0.079 | 0.232 |
LVESd [mm] | 35.2 ± 5.4 | 34.1 ± 3.6 | 34.3 ± 4.2 | 33.8 ± 4.8 | 32.2 ± 4.6 | 0.093 | 0.108 | 0.009 | 0.002 | 0.580 | 0.015 | 0.016 |
PWDd [mm] | 12.2 ± 1.4 | 12.0 ± 1.4 | 11.7 ± 1.3 | 11.7 ± 1.7 | 11.0 ± 1.3 | 0.872 | 0.009 | 0.016 | < 0.001 | 0.684 | 0.011 | 0.072 |
PWSd [mm] | 15.4 ± 1.1 | 16.2 ± 1.6 | 16.4 ± 2.0 | 16.1 ± 2.1 | 17.2 ± 2.1 | 0.129 | 0.098 | 0.353 | 0.001 | 0.657 | 0.011 | 0.016 |
IVSDd [mm] | 13.5 ± 1.3 | 13.2 ± 0.8 | 13.1 ± 0.8 | 12.0 ± 0.7 | 11.7 ± 1.2 | 0.362 | 0.245 | 0.002 | < 0.001 | 0.421 | 0.017 | 0.048 |
IVSSd [mm] | 16.2 ± 1.4 | 16.4 ± 1.2 | 17.8 ± 2.2 | 16.9 ± 2.1 | 17.5 ± 1.8 | 0.675 | 0.002 | 0.021 | < 0.001 | 0.173 | 0.534 | 0.426 |
LVM indices | ||||||||||||
LVM [g] | 321 ± 70 | 323 ± 74 | 320 ± 71 | 309 ± 73 | 281 ± 65 | 0.866 | 0.354 | 0.011 | < 0.001 | 0.191 | < 0.001 | 0.003 |
LVMI [g/m2] | 171 ± 36 | 171 ± 33 | 170 ± 34 | 162 ± 33 | 1459 ± 31 | 0.884 | 0.443 | 0.009 | < 0.001 | 0.124 | < 0.001 | 0.002 |
LV volumetric parameters | ||||||||||||
LVEDV [ml] | 135 ± 28 | 125 ± 30 | 122 ± 29 | 121 ± 34 | 117 ± 29 | 0.004 | 0.005 | 0.002 | 0.001 | 0.764 | 0.043 | 0.121 |
LVESV [m] | 53.9 ± 19.9 | 50.1 ± 13.5 | 50.4 ± 15.6 | 48.5 ± 18.5 | 42.3 ± 15.3 | 0.059 | 0.118 | 0.021 | 0.005 | 0.439 | 0.008 | 0.011 |
SV [ml] | 81.6 ± 17.1 | 78.2 ± 14.4 | 77.6 ± 17.1 | 76.4 ± 21.0 | 76.1 ± 18.3 | 0.009 | 0.011 | 0.014 | 0.008 | 0.489 | 0.706 | 0.601 |
Cardiac output parameters | ||||||||||||
CO [l/min] | 6.09 ± 0.73 | 5.80 ± 0.69 | 5.72 ± 0.70 | 5.51 ± 0.78 | 5.51 ± 0.63 | 0.031 | 0.010 | 0.008 | 0.003 | 0.664 | 0.212 | 0.923 |
CI [l/min/m2] | 3.31 ± 0.49 | 3.11 ± 0.55 | 3.09 ± 0.47 | 2.96 ± 0.46 | 2.96 ± 0.52 | 0.019 | 0.014 | 0.011 | 0.006 | 0.821 | 0.263 | 0.976 |
Contractility parameters | ||||||||||||
EF [%] | 60.9 ± 9.9 | 59.1 ± 8.8 | 60.8 ± 9.1 | 65.3 ± 8.9 | 65.5 ± 8.8 | 0.892 | 0.859 | 0.002 | 0.001 | 0.233 | 0.002 | 0.601 |