Table 1 Covariable information for non-missing data, by exposure (RAAS blockers / diuretics) and outcome (acute kidney injury)
Exposed (n = 70,476) | Unexposed (n = 70,476) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
AKI | Count | % | Missing (%) | Count | % | Missing (%) | ||||
AKI | 586 | 0.8 | 0.0 | 348 | 0.5 | 0.0 | ||||
No AKI | 69,890 | 99.2 | 0.0 | 70,128 | 99.5 | 0.0 | ||||
Gender | Male (%) | Female (%) | Missing (%) | Male (%) | Female (%) | Missing (%) | ||||
AKI | 358 (61.1) | 228 (38.9) | 0.0 | 202 (58.1) | 146 (42.0) | 0.0 | ||||
No AKI | 38,007 (54.4) | 31,883 (45.6) | 0.0 | 38,163 (54.4) | 31,965 (45.6) | 0.0 | ||||
Age at Exposure | < 65 (%) | 65–74 (%) | > = 75 (%) | Missing (%) | < 65 (%) | 65–74 (%) | > = 75 (%) | Missing (%) | ||
AKI | 229 (39.1) | 179 (30.6) | 178 (30.4) | 0.0 | 137 (39.4) | 108 (31.0) | 103 (29.6) | 0.0 | ||
No AKI | 37,096 (53.1) | 19,409 (27.8) | 13,385 (19.2) | 0.0 | 36,589 (52.2) | 20,331 (29.0) | 13,208 (18.8) | 0.0 | ||
Diagnosis to Exposure | < 30 days (%) | 30–179 (%) | 180–364 (%) | > = 365 (%) | Missing (%) | < 30 days (%) | 30–179 (%) | 180–364 (%) | > = 365 (%) | Missing (%) |
AKI | 191 (32.6) | 83 (14.2) | 42 (7.2) | 270 (46.1) | 0.0 | 39 (11.3) | 115 (33.2) | 35 (10.1) | 157 (45.4) | 0.0 |
No AKI | 26,347 (37.7) | 8880 (12.7) | 4015 (5.7) | 30,648 (43.9) | 0.0 | 7203 (10.3) | 25,894 (36.9) | 5736 (8.2) | 31,297 (44.6) | 0.0 |
# Medications | 1 (%) | > = 2 (%) | Missing (%) | 1 (%) | > = 2 (%) | Missing (%) | ||||
AKI | 256 (43.7) | 330 (56.3) | 0.0 | 297 (85.8) | 49 (14.2) | 0.0 | ||||
No AKI | 34,803 (49.8) | 35,087 (50.2) | 0.0 | 60,292 (86.0) | 9838 (14.0) | 0.0 | ||||
# GP Consultation | < 10 (%) | 10–19 (%) | 20–29 (%) | > = 30 (%) | Missing (%) | < 10 (%) | 10–19 (%) | 20–29 (%) | > = 30 (%) | Missing (%) |
AKI | 142 (24.2) | 192 (32.8) | 126 (21.5) | 126 (21.5) | 0.0 | 72 (20.7) | 123 (35.3) | 74 (21.3) | 79 (22.7) | 0.0 |
No AKI | 20,781 (29.7) | 24,887 (35.6) | 12,814 (18.3) | 11,408 (16.3) | 0.0 | 18,615 (26.5) | 26,116 (37.2) | 13,457 (19.2) | 11,940 (17.0) | 0.0 |
Systolic Blood Pressure | < 120 (%) | 120–139 (%) | 140–159 (%) | > = 160 (%) | Missing (%) | < 120 (%) | 120–139 (%) | 140–159 (%) | > = 160 (%) | Missing (%) |
AKI | 30 (5.5) | 139 (25.4) | 226 (41.2) | 153 (27.9) | 6.5 | 25 (7.3) | 131 (38.3) | 150 (43.9) | 36 (10.5) | 1.7 |
No AKI | 2089 (3.2) | 13,458 (20.8) | 30,641 (47.3) | 18,637 (28.8) | 7.2 | 5202 (7.7) | 24,012 (35.6) | 28,854 (42.7) | 9479 (14.0) | 3.7 |
Smoking | Yes (%) | No (%) | Ex (%) | Missing (%) | Yes (%) | No (%) | Ex (%) | Missing (%) | ||
AKI | 115 (19.8) | 247 (42.5) | 219 (37.7) | 71 (20.4) | 156 (44.8) | 121 (34.8) | 0.0 | |||
No AKI | 12,260 (17.6) | 34,823 (50.1) | 22,487 (32.3) | 12,104 (17.3) | 35,521 (50.8) | 22,364 (32.0) | 0.2 | |||
GFR | > = 60 (%) | 45–59 (%) | < 45 (%) | Missing (%) | > = 60 (%) | 45–59 (%) | < 45 (%) | Missing (%) | ||
AKI | 398 (77.7) | 81 (15.8) | 33 (6.5) | 239 (76.1) | 55 (17.5) | 20 (6.4) | 9.8 | |||
No AKI | 42,103 (85.8) | 5883 (12.0) | 1070 (2.2) | 38,014 (84.9) | 6090 (13.6) | 678 (1.5) | 36.1 | |||
# Chronic Conditions | 1 (%) | > = 2 (%) | Missing (%) | 1 (%) | > = 2 (%) | Missing (%) | ||||
AKI | 417 (71.2) | 169 (28.8) | 285 (82.4) | 61 (17.6) | 0.0 | |||||
No AKI | 56,163 (80.4) | 13,727 (19.6) | 61,945 (88.3) | 8185 (11.7) | 0.0 | |||||