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Table 2 Acute kidney injury rates (per 1000 person-years) by covariables (non-missing)

From: Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system inhibitors: A population based cohort study using the clinical practice research datalink

 

Exposed (n = 70,476)

Unexposed (n = 70,476)

Overall

Rate (95% CI)1

   

Rate (95% CI)

   

2.54 (2.34–2.76)

   

1.7 (1.53–1.89)

   

Gender

Male

Female

  

Male

Female

  

2.84 (2.56–3.15)

2.18 (1.91–2.48)

  

1.8 (1.57–2.07)

1.57 (1.33–1.84)

  

Age at Exposure

< 65

65–74

> = 75

 

< 65

65–74

> = 75

 

1.82 (1.6–2.08)

2.8 (2.41–3.24)

4.35 (3.75–5.03)

 

1.22 (1.03–1.45)

1.82 (1.51–2.2)

2.99 (2.46–3.563)

 

Diagnosis to Exposure

<  30 days

30–179

180–364

> = 365

<  30 days

30–179

180–364

> = 365

2.24 (1.95–2.59)

3.04 (2.45–3.77)

3.26 (2.41–4.41)

2.56 (2.28–2.89)

2.21 (1.62–3.03)

1.54 (1.28–1.84)

2.14 (1.54–2.98)

1.65 (1.41–1.93)

# Medications

1

> = 2

  

1

> = 2

  

2.14 (1.89–2.42)

2.98 (2.67–3.31)

  

1.71 (1.53–1.92)

1.61 (1.22–2.13)

  

# GP Consultation

< 10

10–19

20–29

> = 30

< 10

10–19

20–29

> = 30

1.9 (1.61–2.24)

2.31 (2–2.66)

3.12 (2.62–3.72)

3.9 (3.27–4.64)

1.18 (0.93–1.49)

1.57 (1.32–1.88)

2.01 (1.6–2.52)

2.71 (2.17–3.37)

Systolic Blood Pressure

<  120

120–139

140–159

> = 160

<  120

120–139

140–159

> = 160

4.66

3.18

2.19

2.19

1.37

1.77

1.73

1.34

Smoking

Yes

No

Ex

 

Yes (%)

No (%)

Ex (%)

 

2.63

2.05

3.01

 

2.09

1.49

1.73

 

GFR

> = 60

45–59

<  45

 

> = 60

45–59

<  45

 

2.3

2.6

7.41

 

1.54

1.92

5.33

 

# Chronic Conditions

1

> = 2

  

1

> = 2

  

2.27 (2.06–2.50)

3.61 (3.10–4.19)

  

1.58 (1.40–1.77)

2.64 (2.06–3.40)

  
  1. 1 Numbers in brackets are 95% confidence intervals