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Table 3 Cox Regression Models (n = 140,952)

From: Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin aldosterone system inhibitors: A population based cohort study using the clinical practice research datalink

ModelCovariablesHR (AKI)95% LCI95% UCI
Baseline1Unexposed1  
Exposed1.481.31.7
Baseline + SexUnexposed1  
Exposed1.481.31.7
Male1  
Female0.810.710.92
Baseline + AgeUnexposed1  
Exposed1.481.291.69
<  65 years1  
65–741.531.311.79
> = 752.462.112.88
Baseline + Chronic TimeUnexposed1  
Exposed1.531.331.77
<  30 days1  
30–179 days1.10.891.35
180–364 days1.371.051.78
> = 365 days1.050.891.24
Baseline + CKDUnexposed1  
Exposed1.51.321.72
No CKD1  
CKD1.931.632.27
Baseline + DMUnexposed1  
Exposed1.411.241.61
No DM1  
DM1.891.612.21
Baseline + HFUnexposed1  
Exposed1.411.231.61
No HF1  
HF3.652.744.86
Baseline + HTUnexposed1  
Exposed1.591.391.82
No HT1  
HT0.530.470.61
Baseline + IHDUnexposed1  
Exposed1.51.311.71
No IHD1  
IHD1.1711.37
Baseline + MedicationsUnexposed1  
Exposed1.371.191.58
11  
> = 21.271.111.46
Baseline + GP ConsultationsUnexposed1  
Exposed1.51.311.71
< 101  
10–191.271.071.51
20–291.711.412.07
> = 302.231.842.71
Baseline + SBPUnexposed1  
Exposed1.591.381.83
< 1201  
120–1390.880.651.17
140–1590.710.530.94
> = 1600.680.50.92
Baseline + SmokingUnexposed1  
Exposed1.481.31.69
No1  
Yes1.351.131.6
Ex1.341.161.54
Baseline + GFRUnexposed1  
Exposed1.471.291.68
> = 601  
45–591.291.071.55
<  452.922.23.88
Full ModelUnexposed1  
Exposed1.231.041.45
Full Model (inc meds*exposure)1 (exposed)1.10.911.33
> = 2 (exposed)1.491.062.11
  1. 1 “Baseline” – hazard ratio prior to adjustment for covariable(s)