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Table 1 Donor, Recipient and Transplant baseline characteristics by donor age < 50 years between 50 and 69 years and ≥ 70 years

From: Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age

 All patients
(1127 pts)
Donors < 50 yrs.
(339 pts)
Donors 50–69 yrs.
(496 pts)
Donors ≥70 yrs.
(292 pts)
P value
1A - Donor characteristics
 M/F (%)578/549 (51/49)215/124 (63/37)229/267 (46/54)134/158 (46/54)< 0,01
 eGFR CG (ml/min)99,38126,89 ± 40,6594,68 ± 34,8376,78 ± 28,22< 0,01
 eGFR CKD-EPI(ml/min)83,65103,51 ± 30,3985,79 ± 25,3879,7 ± 22,03< 0,01
 Hypertension (%)511 (49)66 (21)259 (57)186 (68)< 0,01
 Diabetes mellitus (%)78 (8)9 (3)49 (12)20 (8)< 0,01
 Cerebrovascular cause of death (%)747 (72)159 (52)370 (80)218 (81)< 0,01
1B - Recipient characteristics
 M/F (%)721/406 (64/36)217/122 (64/36)305/191 (61/39)199/93 (68/32)0,18
 Mean age (Yrs)59.17 ± 9.4343,99 ± 10,6955,31 ± 9,6662,73 ± 7,93< 0,01
 1st Tx/ More than 1 Tx (%)972/155 (87/13)277/62
(82/18)
427/69 (86/14)268/24
(92/8)
< 0,01
 SKT/DKT (%)1082/45
(96/4)
339/0
(100/0)
481/15 (97/3)262/30
(90/10)
< 0,01
 HD/PD (%)873/ 308 (79/28)279/73 (86/22)390/136 (80/28)204/99 (71/35)< 0,01
 Pretransplant DM 1 or 2/type 2 (%)95/79 (10,2/7)19/14 (6/4)48/35 (10/7)16/30 (16/11)< 0,01
 Pretransplat Hypertension (%)939 (86)267 (81)420 (88)252 (91)< 0,01
 Pretransplant Cardiopathy (%)358 (32)90 (26)164(33)104 (36)< 0,01
 Pretransplant HCV POS (%)91 (8)26 (8)44 (9)21 (8)0,78
1C - Transplant characteristics
 HLA A/B/DR MM (0–2/3–4/5–6) %48/46/632/62/634/57/942/54/40,27
 PRA zero (CDC) at transplantation %66,3636375,40,13
 Cold ischemia time (hours)16,16 ± 5,2215,89 ± 5,3717,80 ± 4,9818,25 ± 4,640,03
 DGF (%)298 (28)74 (23)135 (29)89 (32)0,04
Induction Therapy< 0,01
 ATG (%)21 (2)3 (1)3 (1)9 (3) 
 Basiliximab (%)1080 (98)319 (98)479 (98)282 (99)
Mantaining Therapy< 0,01
 Tacrolimus (%)848 (79)286 (87)360 (77)202 (73) 
 Cyclosporine (%)181 (17)32 (10)95 (20)54 (20)
 mTORi (%)83 (8)27 (11)31 (7)25 (9)
 mTORi at 1 yr(%)169 (15)77 (23)59 (12)33 (11)< 0,01
 ACE/ARB (%)368 (33)190 (56)117 (24)61 (21)< 0,01
End f-up Mantaining Therapy (%)< 0,01
  Tacrolimus (%)839 (78)271 (83)374 (79)194 (69) 
 Cyclosporine (%)133 (12)27 (8)64 (13)42 (15)
 mTORi (%)255 (24)56 (17)124 (26)73 (26)
  1. eGFR = estimated Glomerular filtration rate; CG = Cockroft-Gault formula; CKD-EPI = Chronic Kidney Disease Epidemiology Collaboration; SKT = Single Kidney Transplantation; DKT = Dual Kidney Transplantation; PD = Peritoneal Dialysis; HD = Haemodialysis; DM = Diabetes Mellitus; HCV = Hepatitis C virus; HLA = Human Leucocyte Antigens; MM = Mismatch; PRA = Panel Reactive Antibodies; CDC = Cell Dependent Cytotoxicity; ATG = anti-thymocite globulin; mTORi = mammalian target of rapamycin inhibitors; ACE = angyotensin converting enzyme; ARB = Angiotensin Receptor Blockers; DGF = delayed graft function
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