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Table 1 Clinical and Laboratory Findings at Time of Renal Biopsy

From: Clinical and pathological features of idiopathic membranous nephropathy with focal segmental sclerosis

 

IMN(N = 305)

FSGS-(N = 252)

FSGS+(N = 53)

P value

Age (year)

44.23 ± 13.95

43.62 ± 13.61

46.53 ± 15.09

0.195

Sex (female(%))

114/305 (37.4)

96/252 (38.1)

18/53 (33.9)

0.572

Duration of illness (month)

3.87 ± 4.68

3.46 ± 4.20

5.33 ± 5.93*

0.028

SBP (mmHg)

141.57 ± 19.98

138.03 ± 19.28

152.50 ± 18.46**

0.003

DBP (mmHg)

87.52 ± 13.24

85.68 ± 12.46

93.23 ± 14.23*

0.019

Urine RBC/HPF

13.92 ± 16.72

13.59 ± 15.98

15.18 ± 19.45

0.557

24-HUPRO (g/L)

5.71 ± 3.09

5.60 ± 3.07

6.18 ± 3.19

0.227

WBC (× 109/L)

7.64 ± 3.27

7.61 ± 3.14

7.73 ± 3.77

0.831

HGB (g/L)

136.12 ± 17.36

136.40 ± 17.31

134.82 ± 17.74

0.604

PLT (×109/L)

260.06 ± 61.47

254.64 ± 58.81

280.85 ± 67.45**

0.008

AST (u/L)

23.06 ± 14.14

21.98 ± 10.32

27.16 ± 23.24

0.138

ALT (u/L)

25.55 ± 22.18

24.46 ± 17.49

29.70 ± 34.53

0.145

SOD (u/mL)

96.36 ± 29.21

92.33 ± 26.43

110.57 ± 34.19**

0.005

TP (g/L)

45.58 ± 7.20

45.37 ± 6.78

46.34 ± 8.67

0.408

ALB (g/L)

23.82 ± 5.26

23.77 ± 5.09

24.05 ± 6.05

0.723

GLO (g/L)

21.85 ± 4.59

21.75 ± 4.30

22.19 ± 5.56

0.554

GLU (mmol/L)

5.22 ± 1.41

5.24 ± 1.47

5.12 ± 1.05

0.628

BUN (mmol/L)

5.45 ± 1.91

5.44 ± 1.86

5.49 ± 2.11

0.873

SCr (μmol/L)

66.26 ± 19.03

64.21 ± 18.64

70.28 ± 20.25*

0.036

CysC (mg/L)

1.05 ± 0.29

1.05 ± 0.28

1.06 ± 0.33

0.745

β2-MG (mg/L)

2.25 ± 0.80

2.15 ± 0.66

2.63 ± 1.12**

0.010

RBP (mg/L)

52.32 ± 16.87

51.11 ± 16.52

56.74 ± 17.55*

0.047

Ca (mmol/L)

2.16 ± 0.26

2.15 ± 0.27

2.18 ± 0.21

0.468

CHOL (mmol/L)

8.85 ± 2.72

8.91 ± 2.76

8.63 ± 2.59

0.551

HDL-C (mmol/L)

1.74 ± 0.59

1.75 ± 0.58

1.74 ± 0.62

0.930

LDL-C (mmol/L)

5.33 ± 2.18

5.38 ± 2.19

5.14 ± 2.11

0.531

PLA2R (POSITIVE %)

132/175 (75.4)

98/132 (74.2)

34/43 (79.0)

0.523

IgG4 (mg/L)

313.08 ± 248.47

283.81 ± 223.11

380.84 ± 291.16*

0.044

IgG (g/L)

5.28 ± 2.53

5.23 ± 2.47

5.50 ± 2.81

0.547

IgM (g/L)

1.09 ± 0.54

1.11 ± 0.56

0.99 ± 0.42

0.191

IgA (g/L)

2.20 ± 0.87

2.19 ± 0.79

2.22 ± 1.14

0.912

C3 (g/L)

1.16 ± 0.25

1.16 ± 0.25

1.17 ± 0.25

0.804

C4 (g/L)

0.29 ± 0.08

0.28 ± 0.08

0.29 ± 0.07

0.528

C1q (mg/L)

207.13 ± 41.49

206.48 ± 40.21

210.11 ± 47.18

0.612

  1. Note: SBP systolic blood pressure, DBP diastolic blood pressure, 24-HUPRO 24-h urinary protein, WBC white blood cell, HGB hemoglobin, TP serum total protein, ALB serum albumin, BUN blood urea nitrogen, SCr serum creatinine concentration, SOD superoxide dismutase, CysC cystatin C, RBP blood retinol-binding protein, β2-MG β2-microglobulin, BUN blood urea nitrogen, ALT glutamic pyruvic transaminase, AST glutamic oxaloacetic transaminase, GLB globulin, Ca blood calcium, C3 and C4 serum complement3 and 4, PLA2R phospholipase A2 receptors
  2. Compared with the FSGS- group and the FSGS+ group, P* < 0.05, P** < 0.01