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Table 1 Baseline characteristics of patients with chronic kidney disease stage 3–5 with 5-year follow-upa

From: Validation of the kidney failure risk equation for end-stage kidney disease in Southeast Asia

 

Total patients with CKD (n = 17,271)

Patients with ESKD (n = 491)

Patients without ESKD (n = 16,780)

CKD stages, n (%)

 Stage 3 CKD (30 ≤ eGFR< 60 mL/min/1.73m2)

15,313 (89)

147 (30)

15,166 (90)

 Stage 4 CKD (15 ≤ eGFR< 30 mL/min/1.73m2)

1833 (11)

261 (53)

1572 (9)

 Stage 5 CKD (eGFR< 15 mL/min/1.73m2)

125 (0.72)

83 (17)

42 (0.25)

Demographics

Age (years), mean (SD)

75 (9)

70 (10)

75 (9)

Gender, n (%)

 Men

8461 (49)

233 (48)

8228 (49)

 Women

8810 (51)

258 (53)

8552 (51)

Ethnicity, n (%)

 Chinese

13,837 (80)

356 (73)

13,481 (80)

 Indians

708 (4)

22 (4)

686 (4)

 Malays

2155 (13)

90 (18)

2065 (12)

 Others

571 (3)

23 (5)

548 (4)

Lifestyle factors

 Government housing, n (%)

15,348 (89)

456 (93)

14,892 (89)

 Past or current smoker, n (%)

1097 (6)

42 (9)

1055 (6)

 BMI (kg/m2), mean (SD)

25.5 (4.52)

26.3 (4.31)

25.5 (4.52)

Known co-morbiditiesb

 Physician-diagnosed diabetes mellitus, n (%)

10,129 (59)

396 (81)

9733 (58)

 Physician-diagnosed hypertension, n (%)

17,019 (99)

488 (99)

16,531 (99)

 Physician-diagnosed cardiovascular disease, n (%)

4354 (25)

140 (29)

4214 (25)

 Physician-diagnosed stroke, n (%)

2118 (12)

62 (13)

2056 (12)

Recalibrated Pooled KFRE SEA equationc

  > 3%, n (%)

8229 (48)

482 (98)

7817 (47)

  > 5%, n (%)

6017 (35)

475 (97)

5542 (33)

  > 10%, n (%)

3506 (20)

448 (91)

3058 (18)

  1. aData are expressed as mean (standard deviation) for continuous variables and n (percentage) for categorical variables. CKD was defined as CKD-EPI eGFR < 60 mL/min/1.73m2
  2. bKnown co-morbidities as documented by physicians in the electronic health record
  3. cThe Recalibrated Pooled KFRE SEA equation at 5-year ESKD risk was calculated as: 1–0.8362 ^ exp. (− 0.2245 × (age/10–7.036) + 0.3212 × (male - 0.5642) - 0.4553 × (eGFR/5–7.222) + 0.4469 × (lnACR - 5.137))
  4. Abbreviation: ACR albumin-to-creatinine ratio, BMI body mass index, CKD chronic kidney disease, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration, eGFR estimated glomerular filtration rate, ESKD end-stage kidney disease, KFRE Kidney Failure Risk Equation, SEA Southeast Asia, SD standard deviation