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Table 3 Comparison of predictive performances of existing KFRE equations and recalibrated KFRE equations at 5-year and 2-year risks of ESKD

From: Validation of the kidney failure risk equation for end-stage kidney disease in Southeast Asia

 

KFRE equations

AUC (95% CI)

NRIa (95% CI)

5-year risk

 Existing KFRE equations

Original KFRE [17]

0.94 (0.93–0.95)

0.19% (0.12–0.30%)

Original KFRE calibrated for north American [17]

0.94 (0.93–0.95)

0.19% (0.12–0.30%)

Original KFRE calibrated for non-north American [17]

0.94 (0.93–0.95)

0.21% (0.12–0.30%)

Pooled KFRE [17]

0.94 (0.93–0.95)

−0.11% (− 0.20%--0.06%)

 Recalibrated KFRE equations

Recalibrated Original KFRE SEA 1b

0.94 (0.93–0.95)

0.21% (0.14–0.32%)

Recalibrated Original KFRE SEA 2c

0.94 (0.93–0.95)

1.72% (1.48–1.99%)

Recalibrated Pooled KFRE SEAd

0.94 (0.93–0.95)

–

2-year risk

 Existing KFRE equations

Original KFRE [17]

0.96 (0.95–0.97)

0.03% (0.01–0.09%)

Original KFRE calibrated for north American [17]

0.96 (0.95–0.97)

0.01% (0–0.06%)

Original KFRE calibrated for non-north American [17]

0.96 (0.95–0.97)

0.01% (0–0.06%)

Pooled KFRE [17]

0.96 (0.95–0.97)

0.01% (0–0.06%)

 Recalibrated KFRE equations

Recalibrated Original KFRE SEA 1e

0.96 (0.95–0.97)

0.31% (0.22–0.44%)

Recalibrated Original KFRE SEA 2f

0.96 (0.95–0.97)

−0.23% (− 0.35%--0.15%)

Recalibrated Pooled KFRE SEAg

0.96 (0.95–0.97)

–

  1. aNRI was compared between Recalibrated Pooled KFRE SEA over all other KFRE equations using individual statistical threshold identified by Youden Index to dichotomize
  2. bThe Recalibrated Original KFRE SEA 1 at 5-year ESKD risk was calculated as: 1–0.9595 ^ exp. (− 0.2201 × (age/10–7.036) + 0.2467 × (male – 0.5642) – 0.5567 × (eGFR/5–7.222) + 0.4510 × (logACR – 5.137))
  3. cThe Recalibrated Original KFRE SEA 2 at 5-year ESKD risk was calculated as: 1–0.9595 ^ exp. (− 0.4734 × (age/10–7.036) + 0.0119 × (male – 0.5642) – 0.6990 × (eGFR/5–7.222) + 0.6159 × (logACR – 5.137))
  4. dThe Recalibrated Pooled KFRE SEA at 5-year ESKD risk was calculated as: 1–0.8362 ^ exp. (− 0.2245 × (age/10–7.036) + 0.3212 × (male – 0.5642) – 0.4553 × (eGFR/5–7.222) + 0.4469 × (logACR – 5.137))
  5. eThe Recalibrated Original KFRE SEA 1 at 2-year ESKD risk was calculated as: 1–0.9822 ^ exp. (− 0.2201 × (age/10–7.036) + 0.2467 × (male – 0.5642) – 0.5567 × (eGFR/5–7.222) + 0.4510 × (logACR – 5.137))
  6. fThe Recalibrated Original KFRE SEA 2 at 2-year ESKD risk was calculated as: 1–0.9822 ^ exp. (− 0.4416 × (age/10–7.036) – 0.0723 × (male – 0.5642) – 0.8232 × (eGFR/5–7.222) + 0.5418 × (logACR – 5.137))
  7. gThe Recalibrated Pooled KFRE SEA at 2-year ESKD risk was calculated as: 1–0.8976 ^ exp. (− 0.2245 × (age/10–7.036) + 0.3212 × (male – 0.5642) – 0.4553 × (eGFR/5–7.222) + 0.4469 × (logACR – 5.137))
  8. Abbreviations: AUC area under the receiver operating characteristic curve, CI confidence interval, ESKD end-stage kidney disease, KFRE Kidney Failure Risk Equation, NRI net reclassification improvement, SEA Southeast Asia