Table 4 Summary statistics for selected thresholds of Recalibrated Pooled KFRE SEA equation for 5-year risk of end-stage kidney disease
From: Validation of the kidney failure risk equation for end-stage kidney disease in Southeast Asia
Threshold | Recalibrated Pooled KFRE SEA equationa AUC (95% CI): 0.94 (0.93–0.95) | CKD-EPI eGFR mL/min/1.73m2 AUC (95% CI): 0.89 (0.88–0.91) | |||||||
|---|---|---|---|---|---|---|---|---|---|
> 3% | > 5% | > 10% | > 16% | < 30 | < 35.4 | < 40 | < 45 | < 60 | |
Cumulative n of patients | 8299 (48%) | 6017 (35%) | 3506 (20%) | 2308 (13%) | 1958 (11%) | 3506 (20%) | 5283 (30%) | 7813 (45%) | 17,271 (100%) |
N of patients with CKD needed for evaluation by nephrologists to find one ESKD case | 19.7 (18.2–21.3) | 12.7 (11.6–13.9) | 7.8 (7.2–8.5) | 5.6 (5.0–6.0) | 5.7 (5.2–6.3) | 8.7 (7.9–9.5) | 12.2 (11.1–13.3) | 16.9 (15.6–18.5) | 35.2 (32.3–38.5) |
Risk of ESKD | 5.8% (5.3–6.3%) | 7.9% (7.2–8.6%) | 12.8% (11.7–13.9%) | 18.0% (16.8–20.0%) | 17.6% (16.0–19.3%) | 11.5% (10.5–12.6%) | 8.2% (7.5–9.0%) | 5.9% (5.4–6.4%) | 2.8% (2.6–3.1%) |
Sensitivity (95% CI) | 0.98 (0.97–0.99) | 0.97 (0.96–0.98) | 0.91 (0.90–0.92) | 0.86 (0.85–0.87) | 0.70 (0.68–0.72) | 0.82 (0.80–0.84) | 0.88 (0.87–0.89) | 0.94 (0.93–0.95) | 1.00 (0.99–1.01) |
Specificity (95% CI) | 0.53 (0.51–0.55) | 0.67 (0.66–0.68) | 0.82 (0.81–0.83) | 0.89 (0.88–0.90) | 0.90 (0.89–0.91) | 0.82 (0.81–0.83) | 0.71 (0.70–0.72) | 0.56 (0.55–0.57) | 0.01 (0.00–0.02) |
PPV (95% CI) | 0.05 (0.04–0.06) | 0.07 (0.06–0.08) | 0.10 (0.09–0.11) | 0.16 (0.14–0.18) | 0.18 (0.16–0.20) | 0.11 (0.10–0.12) | 0.08 (0.07–0.09) | 0.06 (0.05–0.07) | 0.03 (0.02–0.04) |
NPV (95% CI) | 0.999 (0.998–1.000) | 0.998 (0.997–0.999) | 0.997 (0.990–1.004) | 0.995 (0.980–1.010) | 0.990 (0.970–1.010) | 0.994 (0.984–1.004) | 0.995 (0.986–1.004) | 0.997 (0.992–1.002) | 1.000 (0.085–1.015) |
LR+ (95% CI) | 2.11 (2.08–2.17) | 2.92 (2.86–3.03) | 5.01 (5.00–5.26) | 7.67 (7.14–8.33) | 7.00 (6.67–7.69) | 4.56 (4.46–4.66) | 3.03 (2.94–3.13) | 2.14 (2.08–2.17) | 1.00 (0.99–1.01) |
LR- (95% CI) | 0.03 (0.02–0.04) | 0.05 (0.04–0.06) | 0.10 (0.09–0.11) | 0.16 (0.14–0.18) | 0.33 (0.31–0.35) | 0.22 (0.21–0.23) | 0.17 (0.16–0.18) | 0.11 (0.10–0.12) | 0.00 (− 0.01–0.01) |