Table 5 Summary statistics for selected thresholds of Recalibrated Pooled KFRE SEA equation for 2-year risk of end-stage kidney disease
From: Validation of the kidney failure risk equation for end-stage kidney disease in Southeast Asia
Threshold | Recalibrated Pooled KFRE SEA equationa AUC (95% CI): 0.96 (0.95–0.97) | CKD-EPI eGFR mL/min/1.73m2 AUC (95% CI): 0.93 (0.92–0.95) | ||||
|---|---|---|---|---|---|---|
> 9% | > 20% | > 40% | > 45% | < 18.8 | < 20 | |
Cumulative n of patients | 2683 (15.4%) | 1240 (7.1%) | 531 (3.0%) | 430 (2.5%) | 430 (2.5%) | 546 (3.1%) |
N of patients with CKD needed for evaluation by nephrologists to find one ESKD case | 8.8 (7.9–9.7) | 4.6 (4.2–5.2) | 2.7 (2.4–3.1) | 2.4 (2.2–2.7) | 2.8 (2.4–3.1) | 3.2 (2.8–3.6) |
Risk of ESKD | 11.4% (10.3–12.7%) | 21.6% (19.4–24.0%) | 36.7% (32.7–40.9%) | 41.6% (37.1–46.3%) | 36.3% (31.9–40.9%) | 31.3% (27.6–35.3%) |
Sensitivity (95% CI) | 0.93 (0.92–0.94) | 0.81 (0.79–0.83) | 0.59 (0.54–0.63) | 0.54 (0.49–0.59) | 0.47 (0.43–0.51) | 0.52 (0.48–0.56) |
Specificity (95% CI) | 0.86 (0.85–0.87) | 0.94 (0.93–0.95) | 0.98 (0.97–0.99) | 0.99 (0.98–1.00) | 0.98 (0.97–0.99) | 0.98 (0.97–0.99) |
PPV (95% CI) | 0.07 (0.06–0.08) | 0.20 (0.19–0.21) | 0.38 (0.37–0.39) | 0.42 (0.37–0.47) | 0.36 (0.32–0.44) | 0.31 (0.27–0.35) |
NPV (95% CI) | 0.999 (0.990–1.008) | 0.997 (0.987–1.007) | 0.992 (0.985–0.999) | 0.992 (0.982–1.002) | 0.989 (0.979–0.999) | 0.991 (0.989–1.001) |
LR+ (95% CI) | 6.68 (6.25–7.14) | 14.3 (12.5–16.7) | 30.1 (27.0–37.8) | 36.8 (25.0–50.0) | 23.5 (16.0–30.3) | 26.0 (20.0–33.3) |
LR- (95% CI) | 0.08 (0.07–0.09) | 0.20 (0.16–0.20) | 0.41 (0.36–0.46) | 0.47 (0.42–0.52) | 0.54 (0.44–0.65) | 0.49 (0.45–0.53) |