Table 1 Characteristics of the overall study population of donors, recipients before transplant, and immunosuppressant medication for Simultaneous Pancreas Kidney transplantation (SPKT) and Kidney Transplantation Alone (KTA) (category 1). Data are shown as mean ± SD. BMI, body mass index; ALT, anti-lymphocyte globulin; ATG, anti-thymocyte globulin; IL-2 RA, Interleukin-2 receptor antagonist; CNI, calcineurin inhibitor; AP drug, antimetabolite; MMF, Mycofenolate mofetil; SRL, sirolimus
Variables | SPK (n = 101) | KTA (n = 26) | P-value |
|---|---|---|---|
Donor | |||
Age, years | 24.2 ± 11.9 | 59.7 ± 17.4 | < 0.001 |
Gender | |||
Male | 60 (69.4%) | 12 (46.2%) | 0.224 |
Female | 41 (40.6%) | 14 (53.8%) | |
BMI, kg/m2 | 22.4 ± 3.1 | 25.4 ± 3.5 | < 0.001 |
Recipient | |||
Age, years | 42.9 ± 8.8 | 61.5 ± 8.6 | < 0.001 |
Gender | |||
Male | 57 (56.4%) | 21 (80.8%) | 0.023 |
Female | 44 (43.6%) | 5 (19.2%) | |
BMI, kg/m2 | 25.1 ± 4.2 | 28.6 ± 3.1 | < 0.001 |
Smokers, n | 21 (21%) | 7 (27%) | 0.501 |
Duration of IDDM, years | 26.6 ± 8.5 | 18.9 ± 8.9 | < 0.001 |
Duration of dialysis, years | 2.7 ± 2.6 | 7.4 ± 4.1 | < 0.001 |
Hypertension | |||
Yes | 87 (86.1%) | 23 (88.5%) | 0.756 |
No | 14 (13.9%) | 3 (11.5%) | |
Blood pressure, mmHg | |||
Systolic | 135 ± 17 | 141 ± 18 | 0.03 |
Diastolic | 76 ± 10 | 82 ± 11 | 0.02 |
Antihypertensive drugs, n | 2.6 ± 1.3 | 2.0 ± 1.5 | 0.046 |
Arterial obstructive disease | |||
Yes | 17 (16.8%) | 8 (30%) | 0.114 |
No | 84 (83.2%) | 18 (70%) | |
Coronary heart disease | |||
Yes | 29 (28.7%) | 19 (73.1%) | < 0.001 |
No | 71 (71.3%) | 7 (26.9%) | |
Time on waiting list, months | 10.4 ± 13.1 | 22.3 ± 28.4 | 0.012 |
Pre-emptive transplant | 22 (24.7%) | 2 (7.7%) | 0.032 |
Immunosuppression | |||
Induction therapy | |||
ALG/ATG | 74 (73.3%) | 4 (15.4%) | 0.001 |
IL2-RA | 19 (18.8%) | 12 (46.2%) | |
None | 8 (7.9%) | 10 (38.5%) | |
CNI | |||
Tacrolimus | 97 (96.0%) | 25 (96.2%) | 0.979 |
Cyclosporin | 4 (4%) | 1 (4.5%) | |
AP drug | |||
MMF | 83 (82.2%) | 22 (84.6%) | 0.002 |
SRL | 14 (13.9%) | 0 | |
Multiple | 3 (3.0%) | 0 | |
None | 1 (1%) | 4 (15.4%) | |