Fig. 4
The evaluation of TSC overdose and hypocalcemia throughout the treatment. a The percentage of Total calcium to ionized calcium (T/I Ca2+) levels below 2.5 at hour 0 and 4 in the RCA-one and RCA-two groups. b The percentage of Total calcium to ionized calcium (T/I Ca2+) levels below 2.5 at hour 0 and 4 in the Saline and RCA-two groups. c The mean concentrations of serum iCa from baseline to 4 h in the Saline and RCA-two groups. The change of concentrations of serum-ionized calcium from baseline to endpoint were analyzed with the mixed models for repeated measures with an unstructured residual covariance matrix (main effect of time P = 0.193, anticoagulation group P < 0.001 and interaction effect P = 0.311). d The mean concentrations of serum iCa from baseline to 4 h in the RCA-one and RCA-two groups. The change of concentrations of serum-ionized calcium from baseline to endpoint were analyzed with the mixed models for repeated measures (main effect of time P = 0.492, anticoagulation group P < 0.001 and interaction effect P = 0.021). e The percentage of hypocalcemia events (iCa2+ < 0.9 mmol/L) between the RCA-one and RCA-two groups. f The percentage of hypocalcemia events (iCa2+ < 0.9 mmol/L) between the Saline and RCA-two groups. (P < 0.05, statistical significance). Abbreviations: Saline, saline flushing group; RCA-two, two-stage regional citrate anticoagulation group; RCA-one, one-stage regional citrate anticoagulation group; n.s., no significant statistical differences; iCa, ionized calcium; TSC, trisodium citrate