Removal of large middle molecules via haemodialysis with medium cut-off membranes at lower blood flow rates: an observational prospective study

Table 3 Reduction ratio (%) for the various uraemic toxins and albumin according to the treatment modalities

Variables	High-flux HD (1)	Predilution OL-HDF (2)	MCO HD (3)	Overall P	post hoc P
Variables	High-flux HD (1)	Predilution OL-HDF (2)	MCO HD (3)	Overall P	(1) vs (2)	(1) vs (3)	(2) vs (3)
Urea	72.5 ± 2.8	72.4 ± 3.9	70.8 ± 5.2	0.7769	0.9686	0.4949	0.5543
Phosphate	57.2 ± 6.1	54.3 ± 16.8	52.6 ± 9.4	0.5976	0.7031	0.3275	0.8228
Creatinine	65.3 ± 3.5	66.2 ± 4.3	63.7 ± 3.8	0.5436	0.699	0.4445	0.2943
Uric acid	77.2 ± 3.3	76.8 ± 2.5	75.2 ± 4.1	0.6338	0.8099	0.3637	0.4297
β2M	74.6 ± 5.2	80.1 ± 4.9^*	72.6 ± 3.8^*	0.0305	0.0811	0.4466	0.0096
Myoglobin	43.5 ± 8.9^*	49.8 ± 7.3^†	63.1 ± 5.3^*†	0.0005	0.2015	0.0003	0.0025
FGF-23	34.6 ± 13.1	35.8 ± 23.2	55.5 ± 20.3	0.1281	0.9192	0.0509	0.1370
κFLC	53.6 ± 15.5	61.5 ± 7.0	63.2 ± 6.0	0.3703	0.2621	0.1668	0.6542
λFLC	26.8 ± 4.4^*	33.0 ± 9.3^a	43.2 ± 5.7^*a	0.0002	0.1589	< 0.0001	0.0368
Albumin	1.7 ± 3.6	2.3 ± 4.1	4.9 ± 2.8	0.2173	0.8041	0.1116	0.2227

Data are expressed as means ± standard deviations. ^*†P < 0.05/3 = 0.0167, ^aP < 0.05 by the post hoc test using the linear mixed model with the least significant difference between two groups
HD haemodialysis, OL-HDF online haemodiafiltration, MCO membrane cut-off, β2M β2-microglobulin, FLC free light chain, FGF fibroblast growth factor

ISSN: 1471-2369