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Table 2 Univariate and multivariate logistic regression analyses for factors associated with NAFLD in CKD patients

From: Noninvasive indices for predicting nonalcoholic fatty liver disease in patients with chronic kidney disease

Variable

Univariate Analysis

Multivariate Analysis

Odds Ratio

95% CI

P

Odds Ratio

95% CI

P

Age (year)

0.991

0.977–1.006

0.243

   

Male

2.277

1.387–3.738

0.001

   

BMI (kg/m2)

1.242

1.164–1.326

< 0.001

3.247

1.849–5.703

< 0.001

Hypertension

1.450

0.772–2.721

0.248

   

Diabetes

1.081

0.684–1.709

0.738

   

Dyslipidemia

2.224

1.241–3.984

0.007

   

Log Creatinine (mg/dL)

0.407

0.262–0.632

< 0.001

   

eGFR (ml/min)

1.050

1.033–1.067

< 0.001

3.538

1.801–6.948

< 0.001

eGFR category (KDIGO)

 G3a (45–59)

Ref

     

 G3b (30–44)

0.236

0.128–0.432

0.533

   

 G4 (15–29)

0.304

0.166–0.557

0.573

   

 G5 (< 15)

0.073

0.031–0.173

< 0.001

   

RRT

0.170

0.023–1.261

0.083

   

EPO use

0.118

0.053–0.260

< 0.001

   

Log White blood cell

2.017

1.067–3.815

0.031

   

Hemoglobin

1.525

1.364–1.706

< 0.001

1.247

1.084–1.434

0.002

Platelet

1.003

1.000–1.006

0.054

   

Log AST (IU/L)

1.626

1.060–2.494

0.026

   

Log ALT (IU/L)

2.137

1.519–3.007

< 0.001

1.644

1.034–2.616

0.035

Log Total bilirubin (mg/dL)

2.874

1.812–4.558

< 0.001

   

Albumin (g/dL)

3.458

2.127–5.621

< 0.001

   

Log CRP

1.088

0.938–1.263

0.266

   

Log Triglyceride (mg/dL)

7.109

4.176–12.104

< 0.001

   

Total cholesterol (mg/dL)

1.007

1.002–1.012

0.003

   

Log Fasting glucose (mg/dL)

2.387

1.236–4.609

0.009

   

HbA1c (%)

9.220

2.046–41.552

0.004

   

TyG index

4.330

2.874–6.522

< 0.001

4.903

3.046–7.893

< 0.001

  1. Abbreviations: NAFLD, nonalcoholic fatty liver disease; CKD, chronic kidney disease; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate; KDIGO, kidney disease improving global outcomes; RRT, renal replacement therapy; EPO, erythropoietin; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CRP, C-reactive protein; HbA1c, hemoglobin A1c; TyG index, triglyceride-glucose index