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Table 1 Baseline Characteristics

From: Furosemide stress test and interstitial fibrosis in kidney biopsies in chronic kidney disease

Variable

Kidney allograft (n = 30)

Native kidneys (n = 54)

Total group (n = 84)

P

Age (y)

34.6 ± 14.8

40.9 ± 15

38.6 ± 15.1

0.071

Gender (M/F) N (%)

18 (60) / 12 (40)

19 (35.2) / 35 (64.8)

37 (44) / 47 (56)

0.028*

Baseline eGFR (ml/min/1.73m2)

47.2 ± 26.8

73.2 ± 45.6

63.9 ± 41.6

0.001*

Serum Albumin (g/dl)

3.8 ± 0.7

2.9 ± 0.8

3.2 ± 0.9

0.000*

Urinary protein excretion (g/g creatinine)

1.62 ± 2.63

4.55 ± 4.52

3.47 ± 4.16

0.002*

Diabetes Mellitus N (%)

23 (76.7)

23 (76.7)

0.000*

Hypertension N (%)

20 (37)

20 (37)

0.000*

Systemic lupus erythematosus N (%)

1 (3.3)

21 (38.9)

22 (26.2)

0.000*

Interstitial Fibrosis N (%)

 Grade I

13 (43.3)

32 (59.3)

45 (53.6)

0.003*

 Grade II

16 (53.3)

11 (20.4)

27 (32.1)

0.003*

 Grade III

1 (3.3)

11 (20.4)

12 (14.3)

0.003*

 Combined

25.3 ± 15.4

28.7 ± 22.3

27.5 ± 20.1

0.409

  1. Data are expressed as mean ± standard deviation, frequency or percentage as appropriate
  2. eGFR estimated glomerular filtration rate, AKI acute kidney injury, FEM furosemide excreted mass, IFI interstitial fibrosis < 25%, IFII interstitial fibrosis 26–50%, IFIII interstitial fibrosis > 50%
  3. *p < 0.05 kidney allograft vs. native kidneys