Long-term renal graft outcome after parathyroidectomy - a retrospective single centre study

BMC Nephrology

Table 3 Factors predictive of eGFR loss at 3 (A) and 12 (B) months after parathyroidectomy

(A) Model for eGFR loss at 3 months Overall fit: R = 0.625	Univariable linear regression			Multivariable linear backward stepwise regression
	ß	CI 95%	p value	ß	CI 95%	p value
Age at transplantation (years)	0.305	0.038 0.573	0.026
Female gender	10.046	4.460 15.632	0.001
Body weight at transplantation (kg)	−0.205	−0.419 0.009	0.060
Last iPTH before parathyroidectomy (pg/ml)	−0.005	−0.013 0.002	0.165	−0.006	− 0,012 0.000	0.043
Time between parathyroidectomy and transplantation (months)	0.114	−0.094 0.321	0.275
Last eGFR before parathyroidectomy (ml/min)	−0.280	−0.399 -0.160	0.000	−0.288	− 0.404 0.172	0.000
(B) Model for eGFR loss at 12 months Overall fit: R = 0.545	Univariable linear regression			Multivariable linear backward stepwise regression
(B) Model for eGFR loss at 12 months Overall fit: R = 0.545	ß	CI 95%	p value	ß	CI 95%	p value
Female gender	4.866	−0.556 10.288	0.077
Body weight at transplantation (kg)	−0.163	−0.354 0.027	0.092
Parathyroidectomy before transplantation	−5.522	−15.444 4.400	0.268
Last iPTH before parathyroidectomy (pg/ml)	−0.008	−0.014 -0.002	0.016
iPTH change after parathyroidectomy (pg/ml)	0.007	0.000 0.014	0.043	0.009	0.002 0.015	0.008
Last serum calcium before parathyroidectomy (mmol/l)	12.473	−1.336 26.282	0.076
Last eGFR before parathyroidectomy (ml/min)	−0.178	−0.296 -0.060	0.004	−0.193	−0.304 -0.082	0.001

The change in eGFR after parathyroidectomy was calculated individually for each patient as the difference between the post-parathyroidectomy value and the eGFR before parathyroidectomy, with negative values representing a loss of eGFR
The overall fit of the models is given in the left upper column head
iPTH change: decrease in iPTH is defined as negative value
CI Confidence interval, eGFR estimated glomerular filtration rate, iPTH intact parathormone

ISSN: 1471-2369