Fig. 1From: SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese familiesTen familial renal glucosuria pedigrees carry SLC5A2 variants. A total of nine different mutations were identified: IVS1-16C > A, c.305C > T/p.(A102V), c.395G > A/p.(R132H), c.736C > T/p.(P246S), c.886(−10_-31)delGCAAGCGGGCAGCTGAACGCCC, c.1152_1163delGGTCATGCTGGC/p.(Val385_Ala388del), c.1222G > T/p.(D408Y), c.1496G > A/p.(R499H) and c.1540C > T/p.(P514S); two novel mutations in SLC5A2, c.1222G > T/p.(D408Y) and c.1496G > A/p.(R499H), were identified in the Chinese FRG pedigrees. Ten individuals were heterozygous or compound heterozygous for an SGLT2 mutation, resulting in glucosuria. The missense variants were predicted to be possibly damaging by PolyPhen-2Back to article page