Fig. 1

a and b) H&E staining with marked irregularity of the tubules, tubular cell nuclear pleomorphism and prominent nucleoli (black arrows). c) Mesangial and interstitial congo-red positivity. d) Classic apple green birefringence under polarised light. e) Positive immunohistochemistry after staining with anti-LECT2 antibody. f) Congo-red staining under fluorescent light. g and h) Randomly orientated and non-branching fibrils of 7–11 nm in the glomerular basement membrane and mesangium (Electron microscopy images courtesy of Leicester Royal infirmary Electron Microscopy department)