Table 1 Basic biochemical and immunochemical analysis and differences between control group and chronic kidney disease patients. Quantitative data are shown as median (lower quartile - upper quartile)
Control | CKD patients | p value | |
|---|---|---|---|
N(males/females) | 28 (9/19) | 62 (27/35) | 0.36 |
Age (years) | 48 (27–53.5) | 52 (41–61) | 0.040 |
Systolic blood pressure | 139.5 (127–160,75) | 135 (120–140) | 0.099 |
Diastolic blood pressure | 91.5 (82.25–98.75) | 80 (75–85) | < 0.001 |
Heart rate | 76 (64.75–85) | 75 (70–80) | 0.71 |
Serum creatinine (mg/dl) | 0.78 (0.69–0.95) | 1.44 (1.13–1.92) | < 0.001 |
Urine creatinine (mg/dl) | 113.35 (92.23–161.54) | 74.87 (50.21–107.94) | < 0.001 |
Proteinuria (g/24 h) | – | 1.5 (0.72–2) | – |
eGFR (ml/min/1.73m2) | 91.5 (79.3–99) | 61 (40–91) | < 0.001 |
Serum renalase | 11.1 (2.5–26.5) | 36.1 (18.3–109.1) | < 0.001 |
Urine renalase | 76.4 (26–114) | 25.1 (13.8–104.4) | 0.095 |
Urinary renalase/Cr ratio (ng/mg) | 53.7 (22.7–96.5) | 44 (17.7–172) | 0.99 |
Serum-to-urine renalase ratio | 0.177 (0,023 – 0,94) | 1.146 (0.63–1.75) | < 0.001 |
Fractional excretion of renalase (%) | 4.68 (0.65–21.22) | 1.60 (0.78–3.25) | 0.092 |