Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort

BMC Nephrology

Table 3 Hazard ratios of incident CKD events by quartiles of FEV₁ in men (n = 20,700)

		Q4 (reference)	Q3	Q2	Q1	P value for trend
		4.51(±0.42)	3.79(±0.14)	3.31(±0.14)	2.58(±0.44)
Number (n)	20,700	4813	5176	5388	5323	–
Incident CKD: Main diagnosis (n = 710)	CKD events n (n per 1000 person-years)	130 (0.82)	167 (1.00)	191 (1.16)	222 (1.52)
	Unadjusted	1.00	1.26 (1.00–1.58)	1.56 (1.25–1.95)	2.40 (1.93–2.98)	< 0.001
	Adjusted^a	1.00	1.09 (0.86–1.38)	1.19 (0.94–1.52)	1.46 (1.14–1.89)	0.002
Incident CKD: Main or secondary diagnosis (n = 1021)	CKD events n (n per 1000 person-years)	183 (1.15)	241 (1.45)	287 (1.74)	310 (2.13)
	Unadjusted	1.00	1.29 (1.06–1.56)	1.68 (1.40–2.02)	2.41 (2.01–2.89)	0.000
	Adjusted^a	1.00	1.10 (0.90–1.33)	1.24 (1.02–1.52)	1.43 (1.16–1.77)	< 0.001

^aAdjustments: Age, baseline eGFR, height, BMI, smoking status, cholesterol, history of CVD, history of diabetes, systolic BP, physical activity, social class, ESR (log transformed), BP medication, screening year
Incident CKD events: includes both inpatient hospitalisations and outpatient diagnosis. Main diagnosis = Primary diagnosis, Main or secondary diagnosis = Primary diagnosis or 1st-3rd secondary diagnosis

ISSN: 1471-2369