Table 3 Trajectory of key variables in participants with and without diabetes
Variables | Subgroup | Baseline | Month 3 | Month 6 | Month 9 | Month 12 | p-value | Interaction p |
|---|---|---|---|---|---|---|---|---|
Creatinine | Diabetes | 35.6 (8.3) | 35.1 (8.4) | 40.9 (8.7) | 47.5 (9.2) | 60.8 (9.7) | 0.001 | 0.334 |
No diabetes | 42.8 (4.7) | 43.1 (5.0) | 49.7 (5.3) | 52.8 (5.7) | 53.5 (6.7) | 0.058 | ||
eGFR | Diabetes | 29.6 (4.2) | 32.6 (4.3) | 30.2 (4.5) | 30.0 (4.9) | 20.9 (5.1) | 0.013 | 0.646 |
No diabetes | 25.9 (2.8) | 29.5 (3.1) | 26.8 (3.2) | 25.4 (3.6) | 23.5 (4.2) | 0.205 | ||
Urea | Diabetes | 1.13 (0.17) | 1.07 (0.18) | 1.09 (0.19) | 1.11 (0.22) | 1.34 (0.21) | 0.531 | 0.862 |
No diabetes | 1.02 (0.10) | 1.02 (0.10) | 1.10 (0.11) | 1.04 (0.12) | 1.20 (0.15) | 0.452 | ||
SBP | Diabetes | 153.1 (8.4) | 145.6 (8.7) | 150.8 (9.1) | 162.6 (9.9) | 149.4 (10.3) | 0.030 | 0.006 |
No diabetes | 153.5 (3.6) | 139.2 (8.3) | 144.6 (4.6) | 136.3 (5.0) | 143.9 (6.4) | < 0.0001 | ||
DBP | Diabetes | 86.2 (8.4) | 81.2 (4.6) | 83.8 (4.9) | 83.6 (5.5) | 81.7 (5.6) | 0.193 | 0.174 |
No diabetes | 96.9 (2.4) | 88.9 (2.7) | 88.9 (2.9) | 85.2 (3.2) | 88.7 (4.0) | < 0.0001 | ||
Sodium | Diabetes | 127.6 (3.9) | 130.2 (4.1) | 127.1 (4.4) | 129.6 (5.1) | 131.9 (5.2) | 0.430 | 0.298 |
No diabetes | 138.8 (1.3) | 136.4 (1.9) | 137.7 (1.9) | 141.6 (2.2) | 141.7 (3.1) | 0.256 | ||
Potassium | Diabetes | 4.8 (0.3) | 4.8 (0.3) | 4.6 (0.3) | 4.9 (0.3) | 5.0 (0.4) | 0.542 | 0.935 |
No diabetes | 4.4 (0.1) | 4.3 (0.2) | 4.2 (0.2) | 4.4 (0.2) | 4.4 (0.3) | 0.552 | ||
Calcium | Diabetes | 84.2 (4.0) | 74.7 (4.8) | 84.9 (4.7) | 84.4 (5.7) | 84.2 (5.4) | 0.098 | 0.216 |
No diabetes | 88.9 (1.7) | 89.1 (2.6) | 88.9 (2.2) | 91.9 (2.9) | 90.4 (3.6) | 0.848 | ||
Haemoglobin | Diabetes | 10.0 (0.7) | 9.0 (0.9) | 9.1 (1.1) | 10.3 (1.5) | 12 (1.2) | 0.022 | 0.005 |
No diabetes | 11.2 (0.6) | 10.7 (0.7) | 10.3 (0.7) | 10.0 (0.7) | 9.8 (0.9) | 0.079 | ||
TCMH | Diabetes | 27.2 (1.7) | 27.4 (1.8) | 28.5 (1.8) | 28.2 (2.0) | 28.7 (2.2) | 0.582 | 0.981 |
No diabetes | 30.8 (1.8) | 29.7 (2.5) | 32.5 (2.6) | 31.5 (3.1) | 32.2 (5.9) | 0.908 | ||
VGM | Diabetes | 84.2 (3.0) | 85.3 (4.0) | 93.1 (4.3) | 90.3 (5.1) | 91.8 (4.7) | 0.069 | 0.325 |
No diabetes | 81.2 (2.6) | 75.6 (3.5) | 80.7 (3.9) | 82.0 (4.4) | 92.3 (8.3) | 0.260 | ||
Phosphate | Diabetes | 47.3 (6.2) | 52.1 (8.3) | 43.2 (8.1) | 50.7 (9.1) | 48.3 (7.8) | 0.707 | 0.586 |
No diabetes | 46.4 (4.4) | 39.6 (7.2) | 44.7 (5.7) | 51.3 (7.5) | 35.0 (9.0) | 0.433 | ||
Uric acid | Diabetes | 73.3 (6.5) | 66.1 (7.3) | 69.1 (8.6) | 72.3 (11.3) | 78.0 (14.1) | 0.431 | 0.407 |
No diabetes | 80.9 (4.5) | 68.5 (7.2) | 69.0 (6.2) | 63.0 (8.9) | 56.4 (9.8) | 0.021 | ||
Albumin | Diabetes | 26.4 (2.9) | 30.6 (4.5) | 19.0 (6.9) | 24.2 (13.3) | 21.6 (13.3) | 0.715 | 0.480 |
No diabetes | 33.0 (3.3) | 38.1 (3.9) | 31.2 (4.2) | 33.7 (4.9) | 48.9 (10.1) | 0.150 | ||
Total cholesterol | Diabetes | 1.8 (0.3) | 0.8 (0.4) | 1.3 (0.4) | – | 2.3 (0.4) | 0.307 | 0.889 |
No diabetes | 2.6 (0.2) | 2.3 (0.3) | 1.9 (0.3) | 2.1 (0.3) | 2.6 (0.6) | 0.182 | ||
HDL cholesterol | Diabetes | 0.34 (0.15) | 0.15 (0.21) | 0.21 (0.21) | – | 0.28 (0.26) | 0.626 | 0.852 |
No diabetes | 0.61 (0.08) | 0.34 (0.46) | 0.31 (0.22) | 0.57 (0.33) | 0.92 (0.48) | 0.733 | ||
Triglycerides | Diabetes | 0.93 (0.21) | 0.84 (0.30) | 0.98 (0.32) | – | 0.70 (0.40) | 0.846 | 0.119 |
No diabetes | 2.01 (0.22) | −0.46 (0.48) | 1.63 (0.50) | 1.63 (0.41) | 1.58 (0.57) | 0.118 |