Table 4 Trajectory of key variables in participants with and without hypertension
Variables | Subgroup | Baseline | Month 3 | Month 6 | Month 9 | Month 12 | p-value | Interaction p |
|---|---|---|---|---|---|---|---|---|
Creatinine | Hypertension | 41.5 (6.9) | 41.9 (7.1) | 46.7 (7.2) | 50.9 (7.4) | 58.1 (7.8 | 0.0028 | 0.613 |
No hypertension | 44.7 (6.1) | 41.7 (6.8) | 55.0 (7.4) | 59.7 (8.3) | 64.3 (10.2) | 0.042 | ||
eGFR | Hypertension | 24.1 (3.3) | 26.5 (3.4) | 24.6 (3.5) | 24.3 (3.7) | 17.4 (3.9) | 0.010 | 0.054 |
No hypertension | 23.5 (3.6) | 32.9 (4.3) | 23.8 (5.0) | 19.6 (6.0) | 23.1 (6.9) | 0.030 | ||
Urea | Hypertension | 1.01 (0.12) | 1.06 (0.12) | 1.04 (0.13) | 1.00 (0.14) | 1.22 (0.14) | 0.253 | 0.273 |
No hypertension | 1.09 (0.13) | 0.95 (0.14) | 1.20 (0.16) | 1.16 (0.24) | 1.15 (0.24) | 0.188 | ||
SBP | Hypertension | 163.9 (5.3) | 151.0 (5.7) | 156.1 (5.8) | 159.8 (6.4) | 153.5 (6.9) | 0.0003 | 0.355 |
No hypertension | 138.9 (6.4) | 130.9 (7.1) | 135.0 (7.8) | 125.1 (8.4) | 138.1 (10.3) | 0.099 | ||
DBP | Hypertension | 94.7 (3.2) | 87.5 (3.5) | 89.8 (3.6) | 87.5 (3.9) | 87.5 (4.1) | 0.0002 | 0.713 |
No hypertension | 88.7 (3.6) | 82.6 (4.0) | 82.0 (4.6) | 80.2 (4.8) | 85.4 (5.9) | 0.043 | ||
Sodium | Hypertension | 138.0 (2.4) | 135.1 (2.7) | 138.3 (2.9) | 140.6 (3.2) | 141.6 (3.7) | 0.207 | 0.388 |
No hypertension | 138.4 (1.9) | 139.8 (2.2) | 135.3 (2.5) | 141.5 (3.1) | 141.9 (3.8) | 0.221 | ||
Potassium | Hypertension | 4.54 (0.20) | 4.54 (0.21) | 4.31 (0.22) | 4.53 (0.24) | 4.59 (0.27) | 0.241 | 0.011 |
No hypertension | 5.01 (0.24) | 4.60 (0.30) | 4.98 (0.33) | 5.67(0.41) | 5.08 (0.52) | 0.154 | ||
Calcium | Hypertension | 88.7 (2.6) | 83.2 (3.2) | 89.8 (3.1) | 89.4 (3.5) | 90.0 (3.7) | 0.171 | 0.402 |
No hypertension | 87.8 (2.5) | 91.6 (3.6) | 87.2 (3.4) | 94.5 (5.3) | 81.8 (6.1) | 0.339 | ||
Haemoglobin | Hypertension | 10.8 (0.8) | 10.2 (0.8) | 9.9 (0.8) | 9.7 (0.9) | 10.5 (0.9) | 0.100 | 0.058 |
No hypertension | 9.9 (0.8) | 9.5 (1.0) | 9.1 (2.1) | 10.7 (2.5) | 10.1 (1.9) | 0.960 | ||
TCMH | Hypertension | 29.6 (1.6) | 29.7 (1.9) | 33.2 (1.9) | 30.6 (2.3) | 31.6 (3.0) | 0.153 | 0.351 |
No hypertension | 28.8 (3.9) | 29.1 (4.3) | 23.4 (4.7) | 26.3 (5.1) | 28.4 (6.7) | 0.424 | ||
VGM | Hypertension | 84.3 (3.3) | 80.2 (3.8) | 88.0 (4.0) | 85.3 (4.7) | 92.2 (6.1) | 0.165 | 0.889 |
No hypertension | 77.8 (4.0) | 75.2 (5.4) | 81.6 (5.9) | 83.2 (6.4) | 92.2 (8.3) | 0.425 | ||
Phosphate | Hypertension | 52.6 (5.0) | 51.7 (6.5) | 49.7 (5.8) | 54.4 (6.9) | 51.2 (7.0) | 0.902 | 0.860 |
No hypertension | 44.3 (4.7) | 37.4 (14.9) | 40.5 (7.1) | 67.6 (15.1) | 34.7 (10.4) | 0.516 | ||
Uric acid | Hypertension | 92.4 (6.2) | 82.2 (7.3) | 84.3 (7.1) | 83.6 (8.7) | 79.6 (9.4) | 0.089 | 0.872 |
No hypertension | 72.5 (5.9) | 59.0 (8.6) | 71.9 (11.3) | 65.2 (20.4) | – | 0.347 | ||
Albumin | Hypertension | 33.8 (4.0) | 30.6 (6.6) | 30.9 (5.8) | 28.2 (7.6) | 27.1 (13.1) | 0.825 | 0.246 |
No hypertension | 25.9 (2.8) | 32.0 (3.4) | 23.4 (4.3) | 28.3 (5.1) | 41.3 (9.9) | 0.078 | ||
Total cholesterol | Hypertension | 2.41 (0.20) | 2.00 (0.25) | 1.87 (0.29) | 1.96 (0.34) | 2.66 (0.42) | 0.114 | 0.916 |
No hypertension | 2.24 (0.33) | 2.81 (0.78) | 0.15 (1.19) | 1.72 (0.96) | 1.89 (0.86) | 0.513 | ||
HDL cholesterol | Hypertension | 0.48 (0.12) | 0.32 (0.17) | 0.37 (0.17) | 0.41 (0.33) | 0.50 (0.22) | 0.633 | 0.761 |
No hypertension | 0.57 (0.13) | – | - | 0.00009 (0.35) | – | 0.158 | ||
Triglycerides | Hypertension | 1.83 (0.13) | 0.92 (0.34) | 1.53 (0.31) | 1.82 (0.39) | 1.51 (0.34) | 0.262 | 0.956 |
No hypertension | 1.32 (0.47) | – | – | 1.83 (1.79) | – | Not computable |