Experimental rat model for acute tubular injury induced by high water hardness and high water fluoride: efficacy of primary preventive intervention by distilled water administration

Table 2 Renal histological scores and severity of tubular injury in rats treated with normal water, test water and distilled water for 60 and 90 days

0. No damage
1 Loss of Brush Border (BB) in less than 25% of tubular cells. Integrity of basal membrane
2. Loss of BB in more than 25% of tubular cells, Thickened basal membrane
3. (Plus) Inflammation, Cast formation, Necrosis up to 60% of tubular cells
4. (Plus) Necrosis in more than 60% of tubular cells
0 = no tubular injury, 1–2 = acute tubular injury and 3–4 = chronic tubular injury; ^aminimal loss of brush border and appeared to be negligible.

ISSN: 1471-2369