Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study

Table 4 Association between brain MRI features with domains of cognitive function

MRI features	Best tertile	Middle tertile	Worst tertile	P-value (crude)	P-value (adjusted)^¥
Memory
Presence of microbleeds, n (%)
Lobar	12 (38.7%)	16 (50%)	9 (31.0%)	0.548	0.287
Non-lobar	9 (29%)	4(12.5%)	6 (20.7%)	0.209	0.048
Presence of lacunes ^a, n (%)	12 (38.7%)	16 (50%)	15 (51.7%)	0.279	0.635
Total white matter hyperintensities, mean (SE)	14.0 (1.2)	14.9 (1.2)	18.6 (1.7)	0.058	0.096
Executive function
Presence of microbleeds, n (%)
Lobar	13 (43.3%)	11 (35.5%)	11 (36.7%)	0.821	0.683
Non-lobar	3 (10%)	8 (25.8%)	8 (26.7%)	0.229	0.744
Presence of lacunes^a, n (%)	14 (46.7%)	14 (46.2%)	14 (46.7%)	0.945	0.635
Total white matter hyperintensities, mean (SE)	13.2 (1.0)	16.0 (1.4)	17.4 (1.6)	0.046	0.054
Psychomotor speed
Presence of microbleeds, n (%)
Lobar	12 (40%)	12 (38.7%)	13 (46.6%)	0.633	0.871
Non-lobar	5 (16.7%)	7 (22.6%)	7 (21.9%)	0.445	0.993
Presence of lacunes^a, n (%)	16 (53.3%)	12 (38.7%)	16 (50%)	0.455	0.139
Total white matter hyperintensities, mean (SE)	14.5 (1.2)	14.2 (0.99)	18.6 (1.6)	0.009	0.013

Memory function tested with the 15-WVLT: best tertile mean 43.0 (SD 5.7) n = 31; middle tertile mean 31.0 (SD 2.9) n = 32; worst tertile mean 21.2 (SD 4.4) n = 29. Executive function assessed by the TMT-B: best tertile mean 89.9 (SD 16.3) n = 30; middle tertile mean 142.8 (SD 17.7) n = 32; worst tertile mean 248.8 (SD 47.2) n = 30. Psychomotor speed tested by LDST: best tertile mean 30.1 (SD3 3.1) n = 30; middle tertile mean 23.0 (SD 1.9) n-31; worst tertile mean 15.2 (SD 4.0) n = 32. ^¥linear regression analysis and adjusted for age, gender and educational level. ^aBoth gliotic and hemorrhagic parenchymal defects in the supratentorial white matter, the brain stem and basal ganglia

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