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Table 3 Patients’ characteristics according to eGFR > 55 and ≤ 55 ml/min. Median κ and λ sFLC showed statistically significant differences between the 2 groups. Kappa light chain was the most prevalent chain in the two active MM groups

From: The renal range of the κ/λ sFLC ratio: best strategy to evaluate multiple myeloma in patients with chronic kidney disease

Patients with active MM (N = 347)

Patients without active MM (n = 176)

P value

eGFR > 55 (n = 266)

Median k sFLC (IQR) mg/L

21,35 (10,45-103,25)

eGFR > 55 (n = 146)

Median k sFLC (IQR) mg/L

15,8 (11,14-24,85)

< 0.001

Median λ sFLC (IQR) mg/L

10,45 (6–23,9)

Median λ sFLC (IQR) mg/L

15,2 (11,15-21,02)

0.001

Median sFLC ratio (IQR)

2,2 (0,53-14,88)

Median sFLC ratio (IQR)

1,09 (0,87-1,34)

< 0.001

EGFR ≤ 55 (n = 81)

Median k sFLC (IQR) mg/L

57,7 (15,35–815)

EGFR ≤ 55 (n = 30)

Median k sFLC (IQR) mg/L

55,35 (35,47-94,15)

0,001

Median λ sFLC (IQR) mg/L

17,7 (7,9–149)

Median λ sFLC (IQR) mg/L

35,95 (22,62-62,02)

< 0,001

Median sFLC ratio (IQR)

5,34 (0,107-71,76)

Median sFLC ratio (IQR)

1,31 (0,95-2,08)

0,001

Creatinine mg/dL (IQR)

1,6 (1,24-2,68)

Creatinine mg/Dl (IQR)

2,11 (1,43-2,98)

0,108

eGFR (IQR)

39 (19,5–49)

eGFR (IQR)

28,8 (19,6-50,5)

0,429

  1. eGFR Estimated Glomerular Filtration Rate, IQR Interquartile range, MM Multiple Myeloma, sFLC Serum Free Light-Chain