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Table 3 Hazard ratio for all-cause readmission during 90-day periods after index hospitalization for acute exacerbation of chronic obstructive pulmonary disease, according to acute kidney injury, overall and stratified by age category and sex and chronic kidney disease

From: Association of acute kidney injury with readmissions after hospitalization for acute exacerbation of chronic obstructive pulmonary disease: a population-based study

 

90-day Readmission rate

Unadjusted model

Adjusted modela

P for interaction

AKI (n = 24,833)

Non-AKI (n = 332,157)

HR (95% CI)

P-value

HR (95% CI)

P-value

Overall (n = 356,990)

39.7%

31.0%

1.35 (1.32–1.38)

< 0.001

1.03 (1.00–1.05)

0.04

 

Age category

 40–64 years (n = 122,362)

37.6%

27.8%

1.43 (1.36–1.50)

< 0.001

1.00 (0.95–1.06)

0.86

0.10

 ≥ 65 years (n = 234,628)

40.2%

32.8%

1.29 (1.26–1.32)

< 0.001

1.03 (1.00–1.06)

0.03

Sexb

 Men (n = 149,333)

38,9%

32.2%

1.26 (1.22–1.29)

< 0.001

0.99 (0.96–1.03)

0.59

0.06

 Women (n = 207,436)

40.5%

30.2%

1.43 (1.39–1.48)

< 0.001

1.06 (1.02–1.09)

0.001

Chronic kidney diseasec

 Chronic kidney disease (n = 47,999)

43.0%

40.9%

1.06 (1.03–1.09)

0.001

0.98 (0.95–1.02)

0.21

< 0.001

 No chronic kidney disease (n = 308,991)

35.7%

29.9%

1.22 (1.18–1.26)

< 0.001

1.04 (1.00–1.07)

0.04

  1. Abbreviations: AKI Acute kidney injury, HR Hazard ratio, CI Confidence interval
  2. aCox proportional hazards model adjusting age, sex, race/ethnicity, insurance status, estimated household income, residential status, hospital length-of-stay, hospital state, and Elixhauser comorbidity measures and arrhythmia with generalized estimating equations to account for patient clustering within hospitals
  3. b221 patients with missingness on sex data
  4. cChronic kidney disease was defined by the Elixhauser comorbidities