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Table 2 Urine biomarker concentrations in adult PH cases (n = 11) at first visit and adult controls (n = 47)

From: Urinary monocyte chemoattractant protein 1 associated with calcium oxalate crystallization in patients with primary hyperoxaluria

BiomarkeraCases, Median (IQR)Controls, Median (IQR)OR(95% CI)P
Clusterin0.2 (0.1, 1.8)8.6 (3.2, 16.1)0.170(0.048, 0.604)0.006
Clusterin/Cr0.5 (0.2, 3.2)7.7 (3.9, 16.3)0.247(0.106, 0.574)0.001
NGAL16.0 (1.0, 23.0)2.0 (2.0, 4.0)2.897(1.322, 6.346)0.008
NGAL/Cr34,483 (1818, 56,818)2817 (1747, 3718)4.611(1.890, 11.254)< 0.001
8 IP589 (300, 793)1172 (567, 1712)0.188(0.056, 0.637)0.007
8 IP/Cr1167 (1014, 1405)1063 (695, 1302)4.146(0.615, 27.94)0.14
MCP 138 (9, 81)192 (96, 335)0.159(0.042, 0.596)0.006
MCP 1/Cr87 (38, 147)165 (130, 204)0.268(0.075, 0.957)0.043
L-FABP2.0 (2.0, 2.0)3.3 (2.9, 4.7)~ 0(~ 0, 0.003)0.004
L-FABP/Cr3.8 (2.9, 6.9)3.6 (2.4, 4.8)1.395(0.358, 5.43)0.63
OPN43 (12, 141)855 (386, 1618)0.228(0.093, 0.557)0.001
OPN/Cr93 (44, 284)847 (432, 1441)0.323(0.160, 0.649)0.002
H-FABP293 (255, 1118)2714 (1552, 4553)0.149(0.049, 0.450)< 0.001
H-FABP/Cr1063 (607, 2070)2652 (1674, 3442)0.201(0.060, 0.666)0.009
  1. P-values in bold denote significance at the 0.05 level. IQR is Intraquartile range. OR is odds ratio. 95% CI is for 95% confidence interval
  2. Models were fit using logistic regression
  3. aLog transformations were taken for all urine biomarkers
  4. Units of measure are Clusterin: ng/ml and μg/g Cr; NGAL ng/ml and ng/g Cr, MCP1 pg/ml and pg/g Cr, L-FABP ng/ml and μg/g Cr, OPN ng/ml and μg/g Cr, H-FABP pg/ml and ng/g Cr