Urinary monocyte chemoattractant protein 1 associated with calcium oxalate crystallization in patients with primary hyperoxaluria

Table 2 Urine biomarker concentrations in adult PH cases (n = 11) at first visit and adult controls (n = 47)

Biomarker^a	Cases, Median (IQR)	Controls, Median (IQR)	OR	(95% CI)	P
Clusterin	0.2 (0.1, 1.8)	8.6 (3.2, 16.1)	0.170	(0.048, 0.604)	0.006
Clusterin/Cr	0.5 (0.2, 3.2)	7.7 (3.9, 16.3)	0.247	(0.106, 0.574)	0.001
NGAL	16.0 (1.0, 23.0)	2.0 (2.0, 4.0)	2.897	(1.322, 6.346)	0.008
NGAL/Cr	34,483 (1818, 56,818)	2817 (1747, 3718)	4.611	(1.890, 11.254)	< 0.001
8 IP	589 (300, 793)	1172 (567, 1712)	0.188	(0.056, 0.637)	0.007
8 IP/Cr	1167 (1014, 1405)	1063 (695, 1302)	4.146	(0.615, 27.94)	0.14
MCP 1	38 (9, 81)	192 (96, 335)	0.159	(0.042, 0.596)	0.006
MCP 1/Cr	87 (38, 147)	165 (130, 204)	0.268	(0.075, 0.957)	0.043
L-FABP	2.0 (2.0, 2.0)	3.3 (2.9, 4.7)	~ 0	(~ 0, 0.003)	0.004
L-FABP/Cr	3.8 (2.9, 6.9)	3.6 (2.4, 4.8)	1.395	(0.358, 5.43)	0.63
OPN	43 (12, 141)	855 (386, 1618)	0.228	(0.093, 0.557)	0.001
OPN/Cr	93 (44, 284)	847 (432, 1441)	0.323	(0.160, 0.649)	0.002
H-FABP	293 (255, 1118)	2714 (1552, 4553)	0.149	(0.049, 0.450)	< 0.001
H-FABP/Cr	1063 (607, 2070)	2652 (1674, 3442)	0.201	(0.060, 0.666)	0.009

P-values in bold denote significance at the 0.05 level. IQR is Intraquartile range. OR is odds ratio. 95% CI is for 95% confidence interval
Models were fit using logistic regression
^aLog transformations were taken for all urine biomarkers
Units of measure are Clusterin: ng/ml and μg/g Cr; NGAL ng/ml and ng/g Cr, MCP1 pg/ml and pg/g Cr, L-FABP ng/ml and μg/g Cr, OPN ng/ml and μg/g Cr, H-FABP pg/ml and ng/g Cr

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