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Table 1 Associated factors of AKI in patients with hematologic malignancies

From: Application of group LASSO regression based Bayesian networks in risk factors exploration and disease prediction for acute kidney injury in hospitalized patients with hematologic malignancies

Variate

Total

AKI (%)

χ2

p-value

cOR (95%CI)

Age

  < 29 yr

213

57 (26.8)

0.564

0.453a

2.16 (1.47~3.18)

 30~49 yr

539

78 (14.5)

  

1.00

 50~69 yr

1236

172 (13.9)

  

0.96 (0.72~1.28)

  ≥ 70 yr

407

63 (15.5)

  

1.08 (0.76~1.55)

Gender

 Male

1375

184 (13.4)

10.561

0.001b

1.00

 Female

1020

186 (18.2)

  

1.44 (1.16~1.80)

Comorbidities

 Hypertension

473

75 (15.9)

0.075

0.784b

1.04 (0.79~1.37)

 Diabetes

814

159 (19.5)

15.748

< 0.001b

1.58 (1.26~1.98)

HM category

 Lymphoma

1941

261 (13.4)

31.429

< 0.001b

1.00

 Leukemia

201

48 (23.9)

  

2.02 (1.42~2.86)

 Multiple Myeloma

253

61 (24.1)

  

2.05 (1.49~2.81)

In-hospital Condition

 Emergent

163

41 (25.2)

12.610

< 0.001b

1.94 (1.34~2.82)

 Normal

2232

329 (14.7)

  

1.00

Anti-tumor Treatment

 ASCT

50

13 (26.0)

20.846

< 0.001b

4.37 (2.04~9.36)

 Chemotherapy

2036

334 (16.4)

  

2.24 (1.57~3.79)

 Untreated/palliative

309

23 (7.4)

  

1.00

Liver Function

 ALT (≥40 U/L)

150

35 (23.3)

7.616

< 0.001b

1.74 (1.17~2.58)

 AST (≥35 U/L)

270

62 (23.0)

13.154

< 0.001b

1.76 (1.29~2.39)

 TBiL(≥20.4 μmol/L)

90

17 (18.9)

0.847

0.357b

1.29 (0.75~2.21)

Renal Function

 SCr(≥115 μmol/L)

113

79 (69.9)

269.309

< 0.001b

15.9 (10.44~24.21)

 eGFR(≥90 mL/min/1.73m2)

1650

170 (10.3)

207.618

< 0.001a

1.00

 eGFR(60~89 mL/min/1.73m2)

596

110 (18.4)

  

1.96 (1.51~2.55)

 eGFR(≤59 mL/min/1.73m2)

147

90 (61.2)

  

13.75 (9.52~19.86)

 SUA(≤359 μmol/L)

1619

198 (12.2)

88.388

< 0.001a

1.00

 SUA (360~420 μmol/L)

398

58 (14.6)

  

1.22 (0.89~1.68)

 SUA (421~480 μmol/L)

200

40 (20.0)

  

1.79 (1.23~2.62)

 SUA (≥481 μmol/L)

178

74 (41.6)

  

5.11 (3.66~7.13)

Biochemical Test

 Album (< 35 g/L)

584

156 (26.7)

75.012

< 0.001b

2.72 (2.16~3.43)

 Hemoglobin (< 115 g/L)

1338

297 (22.2)

105.701

< 0.001b

3.85 (2.93~5.04)

 WBC (≥9.5 × 109)

406

102 (25.1)

35.028

< 0.001b

2.15 (1.66~2.79)

 Hyponatremia

325

135 (41.5)

216.335

< 0.001b

5.84 (4.50~7.59)

 Hypernatremia

41

15 (36.6)

  

4.74 (2.47~9.09)

 Hypokalemia

333

122 (36.6)

227.450

< 0.001b

4.59 (3.53~5.97)

 Hyperkalemia

24

20 (83.3)

  

39.69 (13.45~117.15)

  1. AKI acute kidney injury, cOR crude odds ratio, HM hematologic malignancy, ASCT autologous stem cell transplantation, ALT alanine aminotransferase, AST aspartate aminotransferase, TBiL total bilirubin, SCr serum creatinie, eGFR estimated glomerular filtration rate, SUA serum uric acid, WBC white blood cell
  2. a Cochran-Mantel-Haenszel (CMH) test; b Pearson Chi-square Test