Sonographically determined kidney measurements are better able to predict histological changes and a low CKD-EPI eGFR when weighted towards cortical echogenicity

Table 3 Receiver operating characteristic (ROC) analysis of the relationship of significant renal dysfunction and crude and weighted for cortical echogenicity ultrasound parameters to semi-quantitatively graded renal histological changes

	ROC Analysis	MP	GC/N	GC	GS	GO	TA	IF	II
SCr > 1.5 mg/dL	AUROC p	0.503 0.952	0.503 0.964	0.532 0.563	0.623 0.027	0.676 0.002	0.621 0.030	0.656 0.005	0.706 < 0.001
CKD-EPI < 45 ml/min	AUROC p	0.517 0.761	0.509 0.870	0.542 0.460	0.627 0.024	0.683 0.001	0.624 0.028	0.679 0.001	0.710 < 0.001
CT < 8.78 mm	AUROC p	0.516 0.785	0.578 0.198	0.533 0.591	0.476 0.694	0.608 0.075	0.530 0.620	0.580 0.188	0.555 0.366
KL < 109 mm	AUROC p	0.457 0.436	0.480 0.719	0.480 0.724	0.528 0.613	0.656 0.005	0.593 0.093	0.542 0.447	0.511 0.839
KL/H < 0.67	AUROC p	0.393 0.054	0.476 0.671	0.477 0.680	0.636 0.015	0.631 0.019	0.640 0.012	0.630 0.019	0.557 0.304
w-CT < 8.71	AUROC p	0.510 0.873	0.555 0.361	0.535 0.558	0.559 0.327	0.583 0.167	0.627 0.035	0.665 0.006	0.648 0.014
w-KL < 106.5	AUROC p	0.424 0.183	0.492 0.893	0.478 0.700	0.656 0.006	0.657 0.006	0.694 0.001	0.685 0.001	0.687 0.001
w-KL/H < 0.66	AUROC p	0.458 0.463	0.535 0.542	0.516 0.775	0.736 < 0.001	0.693 0.001	0.716 < 0.001	0.714 < 0.001	0.766 < 0.001

MP mesangial proliferation, GC/N glomerular crescents/necrosis, GC glomerular celularity, GS glomerular sclerosis, GO glomerular obsolescence, TA tubular atrophy, IF interstitial fibrosis, II interstitial infiltrate, SCr serum creatinine, AUROC area under the receiver operating characteristic, CKD-EPI chronic kidney disease epidemiology collaboration, CT cortical thickness, KL kidney length, KL/H kidney length/height, w weighted for cortical echogenicity factor

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