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Fig. 1 | BMC Nephrology

Fig. 1

From: Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain

Fig. 1

Microscopic findings of LCPT with crystal. a LCPT with crystal shows swollen tubules with abundant glassy cytoplasm along with an injured tubule that contains proteinaceous material in the lumen in patient #2 (PAS). b In addition, fuchsinophilic crystals are observed in the vacuolar cytoplasm of the tubules in patient #1 (MT). κ-LC is restricted in the tubular cytoplasm which is (c) weak and focal by IF but (d) diffuse by IHC (λ-LC in an inlet) staining in patient #1. EM analysis demonstrates (e, #1) rhomboid or (f, #2) needle-like crystals in the tubular cytoplasm with (e) occasional electron-dense deposits in the lysosome (left bottom). Scale bars indicate 10 μm in LM and 1 μm in EM figures

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