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Table 2 Pathological characteristics of patients with light chain proximal tubulopathy

From: Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain

 Case #1Case #2Case #3Case #4Case #5
PTEC
 LMFocal fuchsinophilic crystal, diffuse vacuolization and swellingFocal vacuolization and diffuse swellingDiffuse vacuolization and swellingDiffuse vacuolizationFocal swelling
 Ig-LCκκλλλ
 IFaFocalFocalDiffuseDiffuseDiffuse
 IHCaDiffuseDiffuseDiffuseDiffuseDiffuse
 EMCrystal (rhomboid), lysosome with EDDCrystal (needle-like), lysosome with EDD and focal dysmorphismIncreased/large/dysmorphic lysosome with mottled appearanceIncreased/large/dysmorphic lysosome with mottled appearanceIncreased/large/dysmorphic lysosome with mottled appearance
ATIbPresent, minimalPresent, minimalPresent, minimalPresentPresent, minimal
IFTAbPresent, minimalPresent, minimalPresentPresentAbsent
Tubular proteinaceous materialPresentPresentAbsentPresentPresent
GlomerulusGS (12.1%)WNLGS (12.5%)GS (18.6%)WNL
Blood vesselFibro-intimal thickeningWNLFibro-intimal thickeningFibro-intimal thickeningFibro-intimal thickening
  1. aFocal IF or IHC staining: positivity in < 50% of the proximal tubule
  2. bMinimal ATI or IFTA: 0–10% of the renal cortex
  3. PTEC Proximal tubule epithelial cell, LM Light microscopy, Ig-LC Immunoglobulin light chain, IF Immunofluorescence, IHC Immunohistochemistry, EM Electron microscopy, EDD Electron-dense deposit, ATI Acute tubular injury, IFTA Interstitial fibrosis with tubular atrophy, GS Global sclerosis, WNL Within normal limit
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