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Fig. 9 | BMC Nephrology

Fig. 9

From: Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin

Fig. 9

Summary of the proposed role of BAI on STZ-induced DN. BAI, and particularly the kidney-targeted BAI-LZM conjugate, produced inhibition of renal fibrosis and inflammation via the NF-κB, TGF-β1/Smad3 and IGF-1/p38 MAPK signaling pathways. BAI and BAI-LZM can harness the body’s cytoprotective pathways to reactivate autophagy (autophagy markers, mTOR and SIRT1) to ameliorate DN outcomes

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BMC Nephrology

ISSN: 1471-2369

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