Fig. 3

a shows renal sections with PAS staining for animals with chronic Thy-1 nephritis sacrificed at day 42. The 3 groups are placebo treated, late treatment with TH1177 and early treatment with TH1177. 200x and 400x magnifications are shown. Scale bars are 100 μm. b shows the average glomerular injury score for the 3 treatment groups. Scores from the middle and poles are added so the score is out of a maximum of 9. Glomerular injury score was reduced from an average of 4.70 ± 0.85 in the placebo group, to 3.57 ± 0.50 (p < 0.01) and 3.44 ± 0.81 (p < 0.05) in the early and late treatment groups respectively. P values are indicated * for < 0.05 and ** for < 0.01. C shows the average glomerular cell numbers for the 3 treatment groups