Fig. 2From: Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in ratsBBG and inflammation. BBG reduces the infiltration of macrophages in the renal interstitium and the mRNA expression of IL1-β in UUO. a Graphical representation of CD68 surface density in tubular cells in renal cortex. The graphic presents aligned dot plot and mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. # p < 0.05 vs UUO-V and both SHAM groups. b Representative immunostaining of the renal cortex from UUO-V group. c UUO-BBG group. d Graphical representation of CD68 surface density in tubular cells in renal medulla. The graphic shows aligned dot plot and the mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. # p < 0.05 vs UUO-V and both SHAM groups. Representative immunostaining of the renal cortex from (e) UUO-V group and (f) UUO-BBG group. All pictures of the sham control groups are shown in the supplement. Bar = 100 μm in all Figs. (g) Graphical representation of the mRNA expression of IL1-β by semiquantitative RT-PCR. Quantification of densitometric values obtained from the ratio IL1-β /Ciclophilin (mean ± SEM, n = 5) under the 3 experimental conditions indicated on the abscissa. * p < 0.05 vs UUO-BBG and both SHAM groupsBack to article page